Replication of cowpox virus in macrophages is dependent on the host range factor p28/N1R

被引：0
作者：
Daniel Bourquain
Livia Schrick
Bernd Karsten Tischer
Klaus Osterrieder
Lars Schaade
Andreas Nitsche
机构：
[1] Robert Koch Institute,Centre for Biological Threats and Special Pathogens 1
[2] Freie Universität Berlin,Institute of Virology, Department of Veterinary Medicine
[3] City University of Hong Kong,Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences
来源：
Virology Journal | / 18卷
关键词：
Orthopoxvirus; Cowpox virus; Host range; p28; RING finger;
D O I：
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摘要：
Zoonotic orthopoxvirus infections continue to represent a threat to human health. The disease caused by distinct orthopoxviruses differs in terms of symptoms and severity, which may be explained by the unique repertoire of virus factors that modulate the host’s immune response and cellular machinery. We report here on the construction of recombinant cowpox viruses (CPXV) which either lack the host range factor p28 completely or express truncated variants of p28. We show that p28 is essential for CPXV replication in macrophages of human or mouse origin and that the C-terminal RING finger domain of p28 is necessary to allow CPXV replication in macrophages.
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