Circulating and Endometrial Regulatory T Cell and Related Populations in Endometriosis and Infertility: Endometriosis Is Associated with Blunting of Endometrial Cyclical Effects and Reduced Proportions in Moderate-Severe Disease

被引：0

作者：

A. J. Hey-Cunningham

A. Riaz

P. D. Fromm

F. Kupresanin

R. Markham

H. M. McGuire

机构：

[1] The University of Sydney,The University of Sydney Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health

[2] The University of Sydney,Dendritic Cell Research Group, ANZAC Research Institute

[3] The University of Sydney,Ramaciotti Facility for Human Systems Biology and Discipline of Pathology, Charles Perkins Centre

来源：

Reproductive Sciences | 2022年 / 29卷

关键词：

Blood; Regulatory T cells; Endometrium; Endometriosis; Infertility; Menstrual cycle;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Evidence to date supports regulatory T cell (Treg) alterations in endometriosis; however, the relationship remains unclear, and Tregs have not previously been investigated with respect to infertility in endometriosis. This prospective cross-sectional cohort study details circulating and endometrial tissue-specific disturbances in Tregs and broader gated populations in women of reproductive age with and without endometriosis (n = 57 and 29, respectively) using flow cytometry and immunohistochemistry. Participants were characterised by menstrual cycle phase, r-ASRM endometriosis disease stage and fertility status.

引用

页码：229 / 242

页数：13

共 4 条

[1] Circulating and Endometrial Regulatory T Cell and Related Populations in Endometriosis and Infertility: Endometriosis Is Associated with Blunting of Endometrial Cyclical Effects and Reduced Proportions in Moderate-Severe Disease
Hey-Cunningham, A. J.
Riaz, A.
Fromm, P. D.
Kupresanin, F.
Markham, R.
McGuire, H. M.
REPRODUCTIVE SCIENCES, 2022, 29 (01) : 229 - 242
[2] Endometrial stromal cell inflammatory phenotype during severe ovarian endometriosis as a cause of endometriosis-associated infertility
Anupa, Geethadevi
Poorasamy, Jeevitha
Bhat, Muzaffer A.
Sharma, Jai Bhagwan
Sengupta, Jayasree
Ghosh, Debabrata
REPRODUCTIVE BIOMEDICINE ONLINE, 2020, 41 (04) : 623 - 639
[3] Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility
Koval, Halyna D.
Chopyak, Valentyna V.
Kamyshnyi, Oleksandr M.
Kurpisz, Maciej K.
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 43 (01) : 90 - 96
[4] Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue
Jasper, Melinda J.
Tremellen, Kelton P.
Robertson, Sarah A.
MOLECULAR HUMAN REPRODUCTION, 2006, 12 (05) : 301 - 308

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