Insulin Resistance in Experimental Type 1 Diabetes Mellitus

被引：0
|
作者：
V. V. Ivanov
E. E. Buyko
A. A. Ufandeev
K. I. Nevskaya
V. V. Udut
A. P. Zima
T. V. Saprina
E. V. Udut
机构：
[1] Ministry of Health of the Russian Federation,Siberian State Medical University
[2] Tomsk National Research Medical Center,E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
[3] Russian Academy of Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2022年 / 172卷
关键词：
type 1 diabetes mellitus; insulin resistance; glucose utilization rate constant; triacylglycerols; free fatty acids;
D O I：
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学科分类号：
摘要：
Experimental type 1 diabetes mellitus (T1DM) was induced in rats by daily intraperitoneal injections of alloxan in a dose of 90 mg/kg for 4 days. For verification of insulin resistance, insulin tolerance test was performed in 2 weeks and the glucose utilization rate constant (KITT) was calculated. The rats demonstrated the main symptoms of T1DM: hypoinsulinemia, hyperglycemia, ketonemia, glucosuria, ketonuria, polydipsia, polyphagia, weight loss, and insulin resistance, as evidenced by a decrease in KITT. The serum content of free fatty acids and triacylglycerols significantly increased. The content of triacylglycerols increased in skeletal muscles and decreased in the liver. A negative linear correlation was found between KITT and triacylglycerol content in muscles. Thus, the development of insulin resistance in experimental T1DM in rats is associated with accumulation of triacylglycerols in skeletal muscles.
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页码：691 / 694
页数：3
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