The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats

被引：0
作者：
Shenghui Li
Ying Tian
Yu Ding
Xinming Jin
Chonghuai Yan
Xiaoming Shen
机构：
[1] Shanghai Jiaotong University School of Medicine,Xin Hua Hospital and School of Public Health
[2] Shanghai Jiaotong University School of Medicine,School of Public Health
[3] Shanghai Institute for Pediatric Research,Xin Hua Hospital
[4] Shanghai Jiaotong University School of Medicine,undefined
[5] Shanghai Key Laboratory of Children’s Environmental Health,undefined
[6] Shanghai Key Laboratory of Children’s Environmental Health,undefined
来源：
Learning & Behavior | 2009年 / 37卷
关键词：
Sleep Deprivation; Water Maze; Morris Water Maze; Escape Latenc; NREM Sleep;
D O I：
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中图分类号：
学科分类号：
摘要：
It is known that rapid eye movement (REM) sleep plays a crucial role in learning and memory. Previous studies have demonstrated that postlearning REM sleep deprivation (RSD) impairs memory consolidation. Most of these studies observed only the effects of RSD on learning and memory. In the present study, we not only investigated the impacts of 48-h RSD on the spatial reference memory of young rats in a Morris water maze, but also specifically examined whether an REM rebound for 24–48 h after 48-h RSD affected the maintenance of spatial reference memory. RSD was induced by the modified multiple platform method, and spatial reference memory was tested in a Morris water maze. The results demonstrated that, compared with the control groups, posttraining RSD for 48 h produced a significant impairment in the retention of acquired spatial reference memory, and the impairment continuously existed after 24 and 48 h of release from sleep deprivation, which indicates that REM sleep plays a critical role in reference memory maintenance and consolidation. Moreover, postlearning RSD may lead to a long-term impairment in the consolidation of newly acquired memories.
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页码：246 / 253
页数：7
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