Treatment options for refractory angina in patients who are not candidates for revascularization

被引：2

作者：

Conti C.R. ^{[1
]}

机构：

[1] University of Florida, Health Science Center, Gainesville, FL 32610-0277

来源：

Current Cardiology Reports | 2006年 / 8卷 / 4期

关键词：

Coronary Artery Bypass Graft; Myocardial Ischemia; Stable Angina; Spinal Cord Stimulation; Ranolazine;

D O I：

10.1007/s11886-006-0058-2

中图分类号：

学科分类号：

摘要：

Patients with refractory angina are those for whom medical therapy has failed to eradicate the angina completely and who have persistent symptoms that are stable but limit their activities of daily living. Approach to management must include the elimination of the secondary causes of this condition and maximum medical therapy, and if angina persists, the consideration of other strategies. Controversy exists regarding the value of transmural myocardial laser revascularization. Enhanced external counterpulsation is clinically effective in approximately 70% of patients. Spinal cord stimulation is not being used clinically in the United States. In the United States, it is still an investigational procedure that is currently being evaluated prospectively in a randomized trial. Ranolazine, an inhibitor of sodium-dependent calcium overload, may prove to be useful in patients with refractory angina. Copyright © 2006 by Current Science Inc.

引用

页码：272 / 276

页数：4

共 17 条

[1]

Conti C.R., The ABCs of modern management of chronic stable angina, Clin Cardiol, 28, pp. 109-110, (2005)

[2]

Allen K.B., Dowling R.D., Fudge T.L., Et al., Comparison of transmyocardial revascularization with medical therapy in patients with refractory angina, N Engl J Med, 341, pp. 1029-1036, (1999)

[3]

Hillis L.D., Lange R.A., Transmyocardial laser revascularization, N Engl J Med, 341, pp. 1075-1076, (1999)

[4]

Arora R.R., Chou T.M., Jain D., Et al., Multicenter study of enhanced external counterpulsation (MUST-EECP): Effect of EECP on exercise-induced myocardial ischemia and anginal episodes, J Am Coll Cardiol, 33, pp. 1833-1840, (1999)

[5]

Michaels A.D., Linnemeier G., Soran O., Et al., Two-year outcomes after enhanced external counterpulsation for stable angina pectoris (from the International EECP Patient Registry [IEPR]), Am J Cardiol, 93, pp. 461-464, (2004)

[6]

Conti C.R., EECP-enhanced external counterpulsation, J Am Coll Cardiol, 33, pp. 1841-1842, (1999)

[7]

Eliasson T., Augustinsson L.E., Mannheimer C., Spinal cord stimulation in severe angina pectoris - Presentation of current studies, indications and clinical experience, Pain, 65, pp. 169-179, (1996)

[8]

Mannheimer C., Augustinsson L.E., Carlsson C.A., Et al., Epidural spinal electrical stimulation in severe angina pectoris, Br Heart J, 59, pp. 56-61, (1988)

[9]

DeJongste M., Haaksma J., Hautvast R., Et al., Effects of spinal cord stimulation on myocardial ischemia during daily life in patients with severe coronary artery disease, Br Heart J, 71, pp. 413-418, (1994)

[10]

Lasagna L., Mosteller F., Felsinger J., Et al., A study of the placebo response, Am J Med, 16, pp. 770-779, (1954)

← 1 2 →