Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE−/− mice by downregulating the HMGB1-RAGE axis

被引:0
|
作者
Ming Liu
Ying Yu
Hong Jiang
Lei Zhang
Pei-pei Zhang
Peng Yu
Jian-guo Jia
Rui-zhen Chen
Yun-zeng Zou
Jun-bo Ge
机构
[1] Shanghai Institute of Cardiovascular Diseases,
[2] Zhongshan Hospital,undefined
[3] Shanghai Medical College,undefined
[4] Fudan University,undefined
[5] Ministry of Public Health Key Laboratory of Heart Diseases,undefined
[6] Zhongshan Hospital,undefined
[7] Shanghai Medical College,undefined
[8] Fudan University,undefined
来源
Acta Pharmacologica Sinica | 2013年 / 34卷
关键词
atherosclerosis; inflammation; simvastatin; ApoE; mice; human umbilical vein endothelial cells (HUVECs); aortic sinus; HMGB1; RAGE; VCAM-1; MCP-1; macrophages;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:830 / 836
页数:6
相关论文
共 50 条
  • [31] Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
    Hong Fan
    Hai-Bin Tang
    Zhe Chen
    Hu-Qing Wang
    Lei Zhang
    Yu Jiang
    Tao Li
    Cai-Feng Yang
    Xiao-Ya Wang
    Xia Li
    Sheng-Xi Wu
    Gui-Lian Zhang
    Journal of Neuroinflammation, 17
  • [32] Inflammation and coagulation abnormalities via the activation of the HMGB1-RAGE/NF-κB and F2/Rho pathways in lung injury induced by acute hypoxia
    Gao, Jing
    Zhang, Zhuo
    Yan, Jia-Yi
    Ge, Yun-Xuan
    Gao, Yue
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023, 52 (02)
  • [33] HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease
    Chandrashekaran, Varun
    Seth, Ratanesh K.
    Dattaroy, Diptadip
    Alhasson, Firas
    Ziolenka, Jacek
    Carson, James
    Berger, Franklin G.
    Kalyanaraman, Balaramari
    Diehl, Anna Mae
    Chatterjee, Saurabh
    REDOX BIOLOGY, 2017, 13 : 8 - 19
  • [34] The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress
    He, Fei
    Gu, Lina
    Cai, Nan
    Ni, Jun
    Liu, Yong
    Zhang, Quan
    Wu, Chao
    INFLAMMATION RESEARCH, 2022, 71 (10-11) : 1245 - 1260
  • [35] AIP1 Suppresses Atherosclerosis by Limiting Hyperlipidemia-Induced Inflammation and Vascular Endothelial Dysfunction
    Huang, Qunhua
    Qin, Lingfeng
    Dai, Shengchuan
    Zhang, Haifeng
    Pasula, Satish
    Zhou, Huanjiao
    Chen, Hong
    Min, Wang
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (04) : 795 - U375
  • [36] Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage
    Wang, Yao
    Wang, Yun-Shan
    Song, Shu-Liang
    Liang, Hao
    Ji, Ai-Guo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 470 (04) : 845 - 850
  • [37] Papaverine Has Therapeutic Potential for Sepsis-Induced Neuropathy in Rats, Possibly via the Modulation of HMGB1-RAGE Axis and Its Antioxidant Prosperities
    Solmaz, Volkan
    Kaya, Mahmut
    Uslu, Fatma Betul
    Atasoy, Ozum
    Erbas, Oytun
    JOURNAL OF INVESTIGATIVE SURGERY, 2022, 35 (01) : 7 - 13
  • [38] ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability
    Huang, Rumin
    Sun, Yan
    Liu, Ruiyi
    Zhu, Boran
    Zhang, Hailou
    Wu, Haoxin
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 327
  • [39] Caprylic acid suppresses inflammation via TLR4/NF-κB signaling and improves atherosclerosis in ApoE-deficient mice
    Xinsheng Zhang
    Changyong Xue
    Qing Xu
    Yong Zhang
    Huizi Li
    Feng Li
    Yinghua Liu
    Changjiang Guo
    Nutrition & Metabolism, 16
  • [40] PSRC1 overexpression attenuates atherosclerosis progression in apoE-/- mice by modulating cholesterol transportation and inflammation
    Guo, Kai
    Hu, Lu
    Xi, Dan
    Zhao, Jinzhen
    Liu, Jichen
    Luo, Tiantian
    Ma, Yusheng
    Lai, Wenyan
    Guo, Zhigang
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2018, 116 : 69 - 80