Post-transplant Lymphoproliferative Disorder (PTLD): Infection, Cancer?

被引：0
作者：
Voorhees T.J. [1 ]
Baiocchi R.A. [1 ,2 ]
机构：
[1] Department of Internal Medicine, Division of Hematology, Ohio State University College of Medicine, 460 West 10th Avenue, Columbus, 43210, OH
[2] Division of Hematology, The Ohio State University, 320 West 10th Avenue, Columbus, 43210, OH
来源：
Current Transplantation Reports | 2016年 / 3卷 / 2期
关键词：
EBV; EBV oncogenesis; EBV transformation; Post-transplant lymphoproliferative disorder;
D O I：
10.1007/s40472-016-0102-0
中图分类号：
学科分类号：
摘要：
Post-transplant lymphoproliferative disorder encompasses a broad spectrum of lymphoid disorders that occur in immune-suppressed patients following solid or hematopoietic stem cell transplantation. The Epstein-Barr virus (EBV) is an oncogenic virus capable of transforming B lymphocytes and is associated with the pathogenesis of multiple benign and malignant lymphoproliferative disorders, including PTLD. This review outlines current knowledge of EBV pathogenesis, its role in B cell immortalization, transformation, and as an etiologic agent in lymphoproliferative disorders in immune-suppressed patients following transplantation. Here, we provide discussion incorporating infectious disease and medical oncology aspects. © 2016, Springer International Publishing AG.
引用
收藏
页码：145 / 153
页数：8
相关论文
共 106 条
[101]  
Dierksheide J.E., Baiocchi R.A., Ferketich A.K., Et al., IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice, Blood, 105, 4, pp. 1558-1565, (2005)
[102]  
Lee T.C., Savoldo B., Barshes N.R., Et al., Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients, Clin Transplant, 20, 3, pp. 389-393, (2006)
[103]  
McAulay K.A., Haque T., Crawford D.H., Tumour necrosis factor gene polymorphism: a predictive factor for the development of post-transplant lymphoproliferative disease, Br J Cancer, 101, 6, pp. 1019-1027, (2009)
[104]  
Babel N., Vergopoulos A., Trappe R.U., Et al., Evidence for genetic susceptibility towards development of posttransplant lymphoproliferative disorder in solid organ recipients, Transplantation, 84, 3, pp. 387-391, (2007)
[105]  
Lustberg M.E., Pelletier R.P., Porcu P., Et al., Human leukocyte antigen type and posttransplant lymphoproliferative disorder, Transplantation, 99, 6, pp. 1220-1225, (2015)
[106]  
Jones K., Wockner L., Thornton A., Et al., HLA class I associations with EBV+ post-transplant lymphoproliferative disorder, Transpl Immunol, 32, 2, pp. 126-130, (2015)
234567891011