Effect of the y chromosome on plasma high-density lipoprotein-cholesterol levels in Y-chromosome-consomic mouse strains

被引：12

作者：

Suto J.-I. ^{[1
]}

Satou K. ^{[2
]}

机构：

[1] Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba

[2] Center for Animal Disease Control and Prevention, National Institute of Animal Health, Tsukuba

来源：

BMC Research Notes | / 7卷 / 1期

基金：

日本学术振兴会;

关键词：

HDL-cholesterol; Sry; Uty; Y-chromosome-consomic mouse strains;

D O I：

10.1186/1756-0500-7-393

中图分类号：

学科分类号：

摘要：

Background: Plasma high-density lipoprotein (HDL)-cholesterol level is a clinically important quantitative phenotype that widely varies among inbred mouse strains. Several genes or loci associated with plasma HDL-cholesterol levels have been identified on autosomes and the X chromosome. In contrast, genes or loci on the Y chromosome have not attracted significant attention hitherto. Therefore, we investigated the effects of the Y chromosome on plasma HDL-cholesterol levels in Y- chromosome-consomic (Y-consomic) mouse strains. Findings. Plasma HDL-cholesterol level data from 16 Y-consomic strains demonstrated that the Y chromosome substitutions significantly altered plasma HDL-cholesterol levels, i.e., variations in the plasma HDL-cholesterol level could be partially explained by Y chromosome genes. We obtained the following results from the genotype data on 30 single nucleotide polymorphisms (SNPs), including nonsynonymous and synonymous SNPs and 9 polymorphisms in Sry: (1) Variation in rs46947134 of Uty was significantly associated with plasma HDL-cholesterol levels. (2) A CAG repeat number polymorphism in Sry was significantly associated with plasma HDL-cholesterol levels. (3) Strains with a certain haplotype of the Mus musculus domesticus-type Y chromosome had significantly lower plasma HDL-cholesterol levels than strains with a certain haplotype of the M. m. musculus-type Y chromosome. Conclusions: The effect of the Y chromosome on plasma HDL-cholesterol levels was confirmed in the Y-consomic strains. We identified several variants associated with plasma HDL-cholesterol levels. Because the physiological significance of various Y-linked genes remains unclear, the results of this study will provide further insights into the functions of Y-linked genes in lipid metabolism. © 2014 Suto and Satou; licensee BioMed Central Ltd.

引用

共 24 条

[1]

Suto J.-I., Matsuura S., Yamanaka H., Sekikawa K., Quantitative trait loci that regulate plasma lipid concentration in hereditary obese KK and KK-A(y) mice, Biochimica et Biophysica Acta - Molecular Basis of Disease, 1453, 3, pp. 385-395, (1999)

[2]

Wang X., Paigen B., Genetics of variation in HDL cholesterol in humans and mice, Circulation Research, 96, 1, pp. 27-42, (2005)

[3]

Kren V., Qi N., Krenova D., Zidek V., Sladka M., Jachymova M., Mikova B., Horky K., Bonne A., Van Lith H.A., Van Zutphen B.F.M., Lau Y.-F.C., Pravenec M., St. Lezin E., Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR, Hypertension, 37, 4, pp. 1147-1152, (2001)

[4]

Shoji M., Tsutaya S., Shimada J., Kojima K., Kasai T., Yasujima M., Lack of association between Y chromosome Alu insertion polymorphism and hypertension, Hypertension Research, 25, 1, pp. 1-3, (2002)

[5]

Charchar F.J., Tomaszewski M., Lacka B., Zakrzewski J., Zukowska-Szczechowska E., Grzeszczak W., Dominiczak A.F., Association of the Human Y Chromosome with Cholesterol Levels in the General Population, Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 2, pp. 308-312, (2004)

[6]

Russo P., Venezia A., Lauria F., Strazzullo P., Cappuccio F.P., Iacoviello L., Barba G., Siani A., HindIII (+/-) polymorphism of the y chromosome, blood pressure, and serum lipids: No evidence of association in three white populations, Am J Hypertens, 19, pp. 331-338, (2006)

[7]

Hiura Y., Fukushima Y., Kokubo Y., Okamura T., Goto Y., Nonogi H., Takahashi R., Iwai N., Effects of the y chromosome on cardiovascular risk factors in Japanese men, Hypertens Res, 31, pp. 1687-1694, (2008)

[8]

Russo P., Siani A., Miller M.A., Karanam S., Esposito T., Gianfrancesco F., Barba G., Lauria F., Strazzullo P., Cappuccio F.P., Genetic variants of y chromosome are associated with a protective lipid profile in black men, Arterioscler Thromb Vasc Biol, 28, pp. 1569-1574, (2008)

[9]

Charchar F.J., Bloomer L.D., Barnes T.A., Cowley M.J., Nelson C.P., Wang Y., Denniff M., Debiec R., Christofidou P., Nankervis S., Dominiczak A.F., Bani-Mustafa A., Balmforth A.J., Hall A.S., Erdmann J., Cambien F., Deloukas P., Hengstenberg C., Packard C., Schunkert H., Ouwehand W.H., Ford I., Goodall A.H., Jobling M.A., Samani N.J., Tomaszewski M., Inheritance of coronary artery disease in men: An analysis of the role of the y chromosome, Lancet, 379, pp. 915-922, (2012)

[10]

Suto J., Genetic dissection of testis weight in a mouse strain having an extremely large testis: Major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains, Proc Jpn Acad ser B, 84, pp. 393-406, (2008)

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