The Role of P53 in Human Cancer

被引：0
作者：
David Malkin
机构：
[1] University of Toronto,Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children
来源：
Journal of Neuro-Oncology | 2001年 / 51卷
关键词：
p53; tumor suppressor gene; apoptosis; growth arrest; DNA repair;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the two decades since its original discovery, p53 has found a singularly prominent place in our understanding of human cancer. Although the biochemistry of p53 has been worked out in some detail, our knowledge of the biologic consequences of p53 dysfunction is still quite rudimentary. Over the next several years, it will be important to determine how best to harness the complex properties of p53's ability to induce cellular growth arrest and cell death to generate novel, effective approaches to cancer therapy. Furthermore, a clearer appreciation of the direct interaction of epigenetic factors with p53 will lead to development of strategies to inhibit tumour initiation and progression. The next decade promises to offer exciting opportunities to apply our vast knowledge of this intriguing tumor suppressor to clinical advantage.
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页码：231 / 243
页数：12
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