Germline PAX5 mutations and B cell leukemia

被引：0

作者：

R Katherine Hyde

P Paul Liu

机构：

[1] Genetics and Molecular Biology Branch,

[2] National Human Genome Research Institute,undefined

[3] US National Institutes of Health,undefined

来源：

Nature Genetics | 2013年 / 45卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.

引用

页码：1104 / 1105

页数：1

共 50 条

[41] Identification of Pax5 target genes in early B cell differentiation [J].

Pridans, Clare ;

Holmes, Melissa L. ;

Polli, Matthew ;

Wettenhall, James M. ;

Dakic, Aleksandar ;

Corcoran, Lynn M. ;

Smyth, Gordon K. ;

Nutt, Stephen L. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (03) :1719-1728

[42] Reversion of B cell commitment upon loss of Pax5 expression [J].

Mikkola, I ;

Heavey, B ;

Horcher, M ;

Busslinger, M .

SCIENCE, 2002, 297 (5578) :110-113

[43] PAX5 and B-cell neoplasms: transformation through presentation [J].

Thomas-Tikhonenko, Andrei ;

Cozma, Diana .

FUTURE ONCOLOGY, 2008, 4 (01) :5-9

[44] The role of Pax5 in leukemia: diagnosis and prognosis significance [J].

Shahjahani, Mohammad ;

Norozi, Fatemeh ;

Ahmadzadeh, Ahmad ;

Shahrabi, Saeid ;

Tavakoli, Farzaneh ;

Asnafi, Ali Amin ;

Saki, Najmaldin .

MEDICAL ONCOLOGY, 2015, 32 (01)

[45] The regulation of the B-cell gene expression programme by Pax5 [J].

Holmes, Melissa L. ;

Pridans, Clare ;

Nutt, Stephen L. .

IMMUNOLOGY AND CELL BIOLOGY, 2008, 86 (01) :47-53

[46] Large spectre of mutations of PAX5 in LAL-B (V2) [J].

Coyaud, E. ;

Struski, S. ;

Prade, N. ;

Familiades, J. ;

Delabesse, E. ;

Dastugue, N. ;

Brousset, P. ;

Broccardo, C. .

BULLETIN DU CANCER, 2010, 97 :S39-S40

[47] Targeting Hyperactivated Lck in PAX5 Rearranged Pediatric B-Cell Precursors Acute Lymphoblastic Leukemia [J].

Fazio, Grazia ;

Quadri, Manuel ;

Bresolin, Silvia ;

Palmi, Chiara ;

Bardini, Michela ;

Oikonomou, Athanasios ;

Tu, Jia-Wey ;

Scharov, Katerina ;

Peloso, Alberto ;

Watrin, Titus ;

Bhatia, Sanil ;

Borkhardt, Arndt ;

Biondi, Andrea ;

Cazzaniga, Giovanni .

BLOOD, 2022, 140 :3107-3108

[48] Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes [J].

Iwanski, Gabriela B. ;

Thoennissen, Nils H. ;

Nakitandwe, Joy ;

Lin, Patricia ;

Kawamata, Norihiko ;

Nahar, Rahul ;

Ramezani-Rad, Parham ;

Chen, Shann-Ching ;

Shurtleff, Sheila ;

Nowak, Daniel ;

Ruckert, Christian ;

Dugas, Martin ;

Bokemeyer, Carsten ;

Fazio, Grazia ;

Biondi, Andrea ;

Cazzaniga, Giovanni ;

Downing, James R. ;

Mueschen, Markus ;

Koeffler, H. Phillip .

BLOOD, 2010, 116 (21) :1325-1326

[49] PAX8 and PAX5 are differentially expressed in B-cell and T-cell lymphomas [J].

Morgan, Elizabeth A. ;

Pozdnyakova, Olga ;

Nascimento, Alessandra F. ;

Hirsch, Michelle S. .

HISTOPATHOLOGY, 2013, 62 (03) :406-413

[50] PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study [J].

J Familiades ;

M Bousquet ;

M Lafage-Pochitaloff ;

M-C Béné ;

K Beldjord ;

J De Vos ;

N Dastugue ;

E Coyaud ;

S Struski ;

C Quelen ;

N Prade-Houdellier ;

S Dobbelstein ;

J-M Cayuela ;

J Soulier ;

N Grardel ;

C Preudhomme ;

H Cavé ;

O Blanchet ;

V Lhéritier ;

A Delannoy ;

Y Chalandon ;

N Ifrah ;

A Pigneux ;

P Brousset ;

E A Macintyre ;

F Huguet ;

H Dombret ;

C Broccardo ;

É Delabesse .

Leukemia, 2009, 23 :1989-1998

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