Germline PAX5 mutations and B cell leukemia

被引：0

作者：

R Katherine Hyde

P Paul Liu

机构：

[1] Genetics and Molecular Biology Branch,

[2] National Human Genome Research Institute,undefined

[3] US National Institutes of Health,undefined

来源：

Nature Genetics | 2013年 / 45卷

关键词：

D O I：

暂无

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学科分类号：

摘要：

The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.

引用

页码：1104 / 1105

页数：1

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