Germline PAX5 mutations and B cell leukemia

被引：0
作者：
R Katherine Hyde
P Paul Liu
机构：
[1] Genetics and Molecular Biology Branch,
[2] National Human Genome Research Institute,undefined
[3] US National Institutes of Health,undefined
来源：
Nature Genetics | 2013年 / 45卷
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D O I：
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学科分类号：
摘要：
The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.
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页码：1104 / 1105
页数：1
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