Selective retina therapy: Methods, technique, and online dosimetry

被引：15

作者：

Brinkmann R. ^{[1
,4
,5
]}

Schüle G. ^{[1
]}

Neumann J. ^{[1
]}

Framme C. ^{[2
]}

Pörksen E. ^{[3
]}

Elsner H. ^{[3
]}

Theisen-Kunde D. ^{[4
]}

Roider J. ^{[3
]}

Birngruber R. ^{[1
,4
]}

机构：

[1] Medizinisches Laserzentrum Lübeck GmbH, Lübeck

[2] Augenklinik, Universität Regensburg, Regensburg

[3] Klinik für Augenheilkunde, UK-SH, Campus Kiel, Kiel

[4] Institut für Biomedizinische Optik, Universität Zu Lübeck

[5] Institut für Biomedizinische Optik, Universität Zu Lübeck, 23562 Lübeck

来源：

Der Ophthalmologe | 2006年 / 103卷 / 10期

关键词：

Macular edema; Microbubbles; Online dosimetry; Optoacoustic technique; Selective cell effects;

D O I：

10.1007/s00347-006-1416-6

中图分类号：

学科分类号：

摘要：

Selective retina therapy (SRT) is currently under evaluation, as a new and very subtle laser method, for the treatment of retinal disorders associated with a degradation of the retinal pigmentary epithelium (RPE). SRT makes it possible to selevtively effect the RPE, sparing the adjacent neural retina with the photoreceptors and also the choroid below the RPE. In the best case, the therapy leads to regeneration of the RPE and a long-term metabolic increase at the chorio-retinal junction. In contrast to conventional laser photocoagulation, which is associated with complete thermal necrosis of and around the treated site, absolutely no scotoma occurs in SRT. This paper reviews the methods and mechanisms behind the selective effects of the RPE. In vitro and preclinical results are used to describe the bandwidth of selective effects with respect to different irradiation settings. An optoacoustic technique is introduced to visualize effects that cannot be seen by ophthalmoscopy and to facilitate dosimetry control without recourse to angiography completes the report. © 2006 Springer Medizin Verlag.

引用

页码：839 / 849

页数：10

共 48 条

[1] Bresnick G., Diabetic maculopathy: A critical review highlighting diffuse macular edema, Ophthalmology, 90, pp. 1301-1317, (1983)
[2] Figueroa M., Regueras A., Bertrand J., Et al., Laser photocoagulation for macular soft drusen, Retina, 17, pp. 378-384, (1997)
[3] Gabel V.P., Die Lichtabsorption Am Augenhintergrund, (1974)
[4] Schrarmeyer U., Heimann K., Current understanding on the role of retinal pigment epithelium and its pigmentation, Pigment Cell Res, 12, pp. 219-236, (1999)
[5] Ramrattan R.S., Van Der Schaft T., Mooy C., Et al., Morphometric analysis of Bruch,s membrane, the choriocapillaris, and the choroid in aging, Invest Ophthalmol Vis Sci, 35, pp. 2857-2864, (1994)
[6] Moore D.J., Hussain A.A., Marshall J., Age-related variation in the hydraulic conductivity of Bruch,s membrane, Invest Ophthalmol Vis Sci, 36, pp. 1290-1297, (1995)
[7] Roider J., Michaud N.A., Flotte T.J., Et al., Response of the Retinal Pigment Epithelium to Selective Photocoagulation, Arch Ophthalmol, 110, pp. 1786-1792, (1992)
[8] Roider J., Hillenkamp F., Flotte T.J., Et al., Microphotocoagulation: Selective effects of repetitive short laser pulses, Proc Natl Acad Sci, 90, pp. 8643-8647, (1993)
[9] Anderson R.R., Parrish J.A., Selective Photothermolysis: Precise Microsurgery by Selective Absorption of Pulsed Laser Radiation, Science, 220, pp. 524-527, (1983)
[10] Ross E.V., Extended Theory of Selective Photothermolysis: A New Recipe for Hair Cooking?, Lasers Surg Med, 29, pp. 413-415, (2001)

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