Research progress in cation-π interactions

被引:0
作者
JiaGao Cheng
XiaoMin Luo
XiuHua Yan
Zhong Li
Yun Tang
HuaLiang Jiang
WeiLiang Zhu
机构
[1] East China University of Science and Technology,School of Pharmacy
[2] Chinese Academy of Sciences,Drug Discovery and Design Center, Shanghai Institute of Materia Medica
[3] East China University of Science and Technology,School of Sciences
来源
Science in China Series B: Chemistry | 2008年 / 51卷
关键词
cation-π interaction; intermolecular interaction; noncovalent interaction;
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中图分类号
学科分类号
摘要
Cation-π interaction is a potent intermolecular interaction between a cation and an aromatic system, which has been viewed as a new kind of binding force, as being compared with the classical interactions (e.g. hydrogen bonding, electrostatic and hydrophobic interactions). Cation-π interactions have been observed in a wide range of biological contexts. In this paper, we present an overview of the typical cation-π interactions in biological systems, the experimental and theoretical investigations on cation-π interactions, as well as the research results on cation-π interactions in our group.
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页码:709 / 717
页数:8
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  • [1] Meyer E. A.(2003)Interactions with aromatic rings in chemical and biological recognition Angew Chem Int Ed 42 1210-1250
  • [2] Castellano R. K.(1997)The cation-π interaction Chem Rev 97 1303-1324
  • [3] Diederich F.(2000)Molecular clusters of π-systems: theoretical studies of structures, spectra, and origin of interaction energies Chem Rev 100 4145-4186
  • [4] Ma J. C.(1999)Cation-π interactions in structural biology Proc Natl Acad Sci USA 96 9459-9464
  • [5] Dougherty D. A.(1999)Cation-π interactions in proteins: can simple models provide an accurate description? J Am Chem Soc 121 10366-10372
  • [6] Kim K. S.(1986)Amino-aromatic interaction in proteins FEBS Lett 203 139-143
  • [7] Tarakeshwar P.(2004)Structural analysis of cation-π interactions in DNA binding proteins Int J Biol Macromol 34 203-211
  • [8] Lee J. Y.(2000)Synthetic receptors as model for alkali metal cation-π binding sites in proteins Proc Natl Acad Sci USA 97 6271-6276
  • [9] Gallivan J. P.(1993)Stereochemistry of charged nitrogen-aromatic interactions and its involvement in ligand-receptor binding J Comput-Aided Mol Des 7 173-182
  • [10] Dougherty D. A.(2002)Cation-π interactions in ligand recognition and catalysis Trends Pharmcol Sci 23 281-287