A novel `two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans

被引：0

作者：

M. Virginia C. L. Appleyard

William L. McPheat

Michael J. R. Stark

机构：

[1] Department of Biochemistry,

[2] MSI/WTB Complex,undefined

[3] University of Dundee,undefined

[4] Dundee DD1 5EH,undefined

[5] UK e-mail: m.j.r.stark@dundee.ac.uk Tel.: +44 1382 344250 Fax: +44 1382 344782,undefined

[6] Astra Zeneca plc.,undefined

[7] Mereside,undefined

[8] Alderley Park,undefined

[9] Macclesfield,undefined

[10] Cheshire SK10 4TG,undefined

[11] UK,undefined

来源：

Current Genetics | 2000年 / 37卷

关键词：

Key wordsAspergillus nidulans; tcsA gene; Two-component system;

D O I：

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中图分类号：

学科分类号：

摘要：

We have characterised a novel Aspergillus nidulans gene encoding a `two-component' signalling protein (tcsA). tcsA encodes both a histidine kinase domain and a response regulator domain similar to those found in bacterial, lower eukaryotic and plant members of the two-component family of proteins, while two PAS domains in the amino-terminal region of the predicted tcsA product may monitor the signal which regulates a tcsA histidine kinase-response regulator phosphorelay. While tcsA is nonessential for vegetative growth, cells lacking the gene are unable to produce conidia on standard Aspergillus growth media. However, tcsA is not absolutely required for production since this defect is suppressed by growth on 1 M sorbitol.

引用

页码：364 / 372

页数：8