A novel machine-learning framework based on early embryo morphokinetics identifies a feature signature associated with blastocyst development

Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology A(2011)The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting Hum Reprod Oxf Engl 26 1270-83

Storr CA(2017)Inter-observer and intra-observer agreement between embryologists during selection of a single day 5 embryo for transfer: a multicenter study Hum Reprod Oxf Engl 32 307-14

Venetis S(2010)Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Nat Biotechnol 28 1115-21

Cooke S(2020)Good practice recommendations for the use of time-lapse technology† Hum Reprod Open 2020 hoaa008-20

Kilani W(2017)Time-lapse culture with morphokinetic embryo selection improves pregnancy and live birth chances and reduces early pregnancy loss: a meta-analysis Reprod Biomed Online 35 511-71

Ledger CC(2011)The use of morphokinetics as a predictor of embryo implantation Hum Reprod Oxf Engl 26 2658-401

Wong KE(2014)Time-lapse embryo imaging for improving reproductive outcomes: systematic review and meta-analysis Ultrasound Obstet Gynecol off J Int Soc Ultrasound Obstet Gynecol 44 394-30

Loewke NL(2015)A critical appraisal of time-lapse imaging for embryo selection: where are we and where do we need to go? J Assist Reprod Genet 32 1025-26

Bossert B(2017)Does time-lapse imaging have favorable results for embryo incubation and selection compared with conventional methods in clinical in vitro fertilization? A meta-analysis and systematic review of randomized controlled trials PLoS ONE 12 e0178720-9

Behr CJ(2019)Controversies in ART: considerations and risks for uninterrupted embryo culture Reprod Biomed Online 39 19-54

Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology A(2011)The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting Hum Reprod Oxf Engl 26 1270-83

Storr CA(2017)Inter-observer and intra-observer agreement between embryologists during selection of a single day 5 embryo for transfer: a multicenter study Hum Reprod Oxf Engl 32 307-14

Venetis S(2010)Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Nat Biotechnol 28 1115-21

Cooke S(2020)Good practice recommendations for the use of time-lapse technology† Hum Reprod Open 2020 hoaa008-20

Kilani W(2017)Time-lapse culture with morphokinetic embryo selection improves pregnancy and live birth chances and reduces early pregnancy loss: a meta-analysis Reprod Biomed Online 35 511-71

Ledger CC(2011)The use of morphokinetics as a predictor of embryo implantation Hum Reprod Oxf Engl 26 2658-401

Wong KE(2014)Time-lapse embryo imaging for improving reproductive outcomes: systematic review and meta-analysis Ultrasound Obstet Gynecol off J Int Soc Ultrasound Obstet Gynecol 44 394-30

Loewke NL(2015)A critical appraisal of time-lapse imaging for embryo selection: where are we and where do we need to go? J Assist Reprod Genet 32 1025-26

Bossert B(2017)Does time-lapse imaging have favorable results for embryo incubation and selection compared with conventional methods in clinical in vitro fertilization? A meta-analysis and systematic review of randomized controlled trials PLoS ONE 12 e0178720-9

Behr CJ(2019)Controversies in ART: considerations and risks for uninterrupted embryo culture Reprod Biomed Online 39 19-54