Engineering CHO cells for improved central carbon and energy metabolism

被引：5
作者：
Camila A Wilkens
Ziomara P Gerdtzen
机构：
[1] University of Chile,Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology
[2] University of Chile,Millennium Institute for Cell Dynamics and Biotechnology: a Centre for Systems Biology
来源：
BMC Proceedings | / 5卷 / Suppl 8期
关键词：
Fructose; High Cell Density; Lactate Production; Pyruvate Carboxylase; Metabolic Flux Analysis;
D O I：
10.1186/1753-6561-5-S8-P120
中图分类号：
学科分类号：
摘要：
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  • [1] Elias CB(2003)Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme Biotechnol Prog 19 90-97
  • [2] Carpentier E(1999)Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction Biotechnol Bioeng 66 238-246
  • [3] Durocher Y(2007)Engineering cell metabolism for high-density cell culture via manipulation of sugar transport J Biotechnol 131 168-176
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