Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses

Sheikh K(2015)This is what COPD looks like Respirology 26 12611-836

Coxson HO(2014)Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease Int J Chron Obstruct Pulmon Dis 9 825-377

Parraga G(2002)Effects of cigarette smoke on the immune system Nat Rev Immunol 2 372-97

Tse HN(2007)Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations Curr Pharm Des 13 73-555

Tseng CZ(2011)N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV) Biochem Pharmacol 82 548-28

Sopori M(2009)Severe human influenza infections in Thailand: oseltamivir treatment and risk factors for fatal outcome PLoS One 4 e6051-5580

Mallia P(2013)Epidemiological, clinical and viral characteristics of fatal cases of human avian influenza A (H7N9) virus in Zhejiang Province China J Infect 16 00239-5603

Contoli M(2005)Cell type-specific involvement of RIG-I in antiviral response Immunity 23 19-575

Caramori G(2005)Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus J Biol Chem 280 5571-565

Pandit A(2004)Recognition of single-stranded RNA viruses by toll-like receptor 7 Proc Natl Acad Sci U S A 101 5598-1080

Sheikh K(2015)This is what COPD looks like Respirology 26 12611-836

Coxson HO(2014)Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease Int J Chron Obstruct Pulmon Dis 9 825-377

Parraga G(2002)Effects of cigarette smoke on the immune system Nat Rev Immunol 2 372-97

Tse HN(2007)Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations Curr Pharm Des 13 73-555

Tseng CZ(2011)N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV) Biochem Pharmacol 82 548-28

Sopori M(2009)Severe human influenza infections in Thailand: oseltamivir treatment and risk factors for fatal outcome PLoS One 4 e6051-5580

Mallia P(2013)Epidemiological, clinical and viral characteristics of fatal cases of human avian influenza A (H7N9) virus in Zhejiang Province China J Infect 16 00239-5603

Contoli M(2005)Cell type-specific involvement of RIG-I in antiviral response Immunity 23 19-575

Caramori G(2005)Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus J Biol Chem 280 5571-565

Pandit A(2004)Recognition of single-stranded RNA viruses by toll-like receptor 7 Proc Natl Acad Sci U S A 101 5598-1080