Synthesis, physicochemical investigation and biological studies of zinc(II) complexes with 1,2,4-triazole schiff bases

被引：0
作者：
Bagihalli G.B. [1 ]
Patil S.A. [1 ]
Badami P.S. [2 ]
机构：
[1] P.G. Department of Chemistry Karnatak University, Dharwad-580003, Karnataka
[2] Department of Chemistry, Shri Sharanabasaveswar College of Science
来源：
Journal of the Iranian Chemical Society | 2009年 / 6卷 / 2期
关键词：
1,2,4-Triazole; Biological activity; Complexes; Coumarin; Electrochemical; Synthesis;
D O I：
10.1007/BF03245833
中图分类号：
学科分类号：
摘要：
A series of metal complexes of Zn(II) have been synthesized with newly synthesized biologically active 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole with 8-formyl-7-hydroxy-4-methylcoumarin. The structure of the complexes has been proposed in the light of elemental analyses, spectroscopic data (IR, UV-Vis, 1H NMR and FAB-mass), thermal studies. Electrochemical study of the complexes is also reported. All the complexes are soluble to limited extent in common organic solvents but soluble to larger extent in DMF and DMSO and are non-electrolytes in these two solvent. All these Schiff bases and their complexes have also been screened for their antibacterial (Escherichia. coli, S. aureus, S. pyogenes, P. aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and cladosporium) by MIC method. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.
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页码：259 / 270
页数：11
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