Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

被引：0
作者：
Sung Woo Huh
Asode Ananthram Shetty
Jang Mook Kim
Mi-La Cho
Seon Ae Kim
Siyoung Yang
Young Ju Kim
Palaksha Kanive Javaregowda
Nam Yong Choi
Jin Kang
Seok Jung Kim
机构：
[1] The Catholic University of Korea,Department of Orthopaedic Surgery, College of Medicine
[2] Faculty of Health and Wellbeing,Canterbury Christ Church University, Institute of Medical Sciences
[3] College of Health Science,Department of Health Administration
[4] Dankook University,Department of Life Science, College of Medicine, Rheumatism Research Center, Laboratory of Immune Network
[5] The Catholic University of Korea,Department of Pharmacology
[6] Ajou University School of Medicine,Department of Nursing Education & Administration, Uijeongbu St. Mary’s Hospital
[7] The Catholic University of Korea,Biomedical Research Coordinator
[8] SDM College of Medical Sciences & Hospital,Department of Orthopedic Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine
[9] The Catholic University of Korea,Department of Health Administration, College of Health Science
[10] Dankook University,undefined
来源：
Tissue Engineering and Regenerative Medicine | 2016年 / 13卷
关键词：
Osteoarthritis; Total knee arthroplasty; Chondrogenesis; Mesenchymal cell induced chondrogenesis; Economy;
D O I：
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中图分类号：
学科分类号：
摘要：
Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients’ satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.
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页码：200 / 209
页数：9
相关论文
共 144 条
  • [1] Solarino G(2014)Long-term outcome of low contact stress total knee arthroplasty with different mobile bearing designs. Joints 2 109-114
  • [2] Spinarelli A(2015)Ten-year results comparing posterior cruciate-retaining versus posterior cruciate-substituting total knee arthroplasty. J Arthroplasty 30 210-215
  • [3] Carrozzo M(2007)Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 89 780-785
  • [4] Piazzolla A(2014)Results of revision surgery and causes of unstable total knee arthroplasty. Clin Orthop Surg 6 165-172
  • [5] Vicenti G(2014)Local anaesthetic infiltration for peri-operative pain control in total hip and knee replacement: systematic review and meta-analyses of short-and long-term effectiveness. BMC Musculoskelet Disord 15 220-59
  • [6] Moretti B(2013)Simultaneous versus staged bilateral total knee arthroplasty: a meta-analysis evaluating mortality, peri-operative complications and infection rates. HSS J 9 50-233
  • [7] Sando T(2014)Dissatisfied patients after total knee arthroplasty: a registry study involving 114 patients with 8-13 years of followup. Acta Orthop 85 229-479
  • [8] McCalden RW(2012)The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. J Gerontol A Biol Sci Med Sci 67 470-e652
  • [9] Bourne RB(2013)Autologous collagen-induced chondrogenesis: single-stage arthroscopic cartilage repair technique. Orthopedics 36 e648-9
  • [10] MacDonald SJ(2013)Novel repair technique for articular cartilage defect using a fibrin and hyaluronic acid mixture. Tissue Eng Regen Med 10 1-253
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