Serum CGRP in migraine patients using erenumab as preventive treatment

被引:0
作者
Simone de Vries Lentsch
Ingrid M. Garrelds
A. H. Jan Danser
Gisela M. Terwindt
Antoinette MaassenVanDenBrink
机构
[1] Leiden University Medical Centre,Department of Neurology
[2] Erasmus MC University Medical Center,Division of Vascular Medicine and Pharmacology, Department of Internal Medicine
来源
The Journal of Headache and Pain | 2022年 / 23卷
关键词
CGRP; Serum; Monoclonal antibodies; Migraine;
D O I
暂无
中图分类号
学科分类号
摘要
• Lower serum levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity (CGRP-LI) in migraine patients at 2–4 weeks after starting treatment with erenumab were associated with better treatment response after three months.
引用
收藏
相关论文
共 132 条
  • [1] Goadsby PJ(1993)Trigeminovascular System and Migraine: studies Characterizing Cerebrovascular and Neuropeptide Changes Seen in Humans and Cat Annals of neurology 33 48-56
  • [2] Edvinsson L(1990)Vasoactive Peptide Release in the Extracerebral Circulation of Humans During Migraine Headache Annals of neurology 28 183-187
  • [3] Goadsby PJ(2013)Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine Neurology 81 1191-1196
  • [4] Edvinsson L(2010)Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura Cephalalgia 30 1179-1186
  • [5] Ekman R(2018)ARISE: A Phase 3 randomized trial of erenumab for episodic migraine Cephalalgia 38 1026-1037
  • [6] Cernuda-Morollón E(2018)Efficacy and safety of galcanezumab for the prevention of episodic migraine: Results of the EVOLVE-2 Phase 3 randomized controlled clinical trial Cephalalgia 38 1442-1454
  • [7] Larrosa D(2018)Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study The Lancet 392 2280-2287
  • [8] Ramón C(2019)Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomised, double-blind, placebo-controlled, phase 3b trial The Lancet 394 1030-1040
  • [9] Vega J(2020)Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial The Lancet Neurology 19 814-825
  • [10] Martínez-Camblor P(2018)Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial JAMA 319 1999-2008