Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

被引：0

作者：

Anna Köttgen

Eva Albrecht

Alexander Teumer

Veronique Vitart

Jan Krumsiek

Claudia Hundertmark

Giorgio Pistis

Daniela Ruggiero

Conall M O'Seaghdha

Toomas Haller

Qiong Yang

Toshiko Tanaka

Andrew D Johnson

Zoltán Kutalik

Albert V Smith

Julia Shi

Maksim Struchalin

Rita P S Middelberg

Morris J Brown

Angelo L Gaffo

Nicola Pirastu

Guo Li

Caroline Hayward

Tatijana Zemunik

Jennifer Huffman

Loic Yengo

Jing Hua Zhao

Ayse Demirkan

Mary F Feitosa

Xuan Liu

Giovanni Malerba

Lorna M Lopez

Pim van der Harst

Xinzhong Li

Marcus E Kleber

Andrew A Hicks

Ilja M Nolte

Asa Johansson

Federico Murgia

Sarah H Wild

Stephan J L Bakker

John F Peden

Abbas Dehghan

Maristella Steri

Albert Tenesa

Vasiliki Lagou

Perttu Salo

Massimo Mangino

Lynda M Rose

Terho Lehtimäki

机构：

[1] Freiburg University Hospital,Renal Division

[2] Johns Hopkins Bloomberg School of Public Health,Department of Epidemiology

[3] Institute of Genetic Epidemiology,Division of Genetics and Cell Biology

[4] Helmholtz Zentrum München–German Research Center for Environmental Health,Renal Division

[5] Interfaculty Institute for Genetics and Functional Genomics,Department of Biostatistics

[6] Ernst-Moritz-Arndt-University Greifswald,Department of Medical Genetics

[7] Medical Research Council (MRC) Human Genetics Unit,Department of Epidemiology

[8] MRC Institute of Genetics and Molecular Medicine (IGMM),Department of Medicine

[9] University of Edinburgh,Division of Rheumatology

[10] Institute of Bioinformatics and Systems Biology,Subdivision of Genetic Epidemiology, Department of Epidemiology

[11] Helmholtz Zentrum München–German Research Center for Environmental Health,Division of Statistical Genomics, Department of Genetics

[12] San Raffaele Scientific Institute,Department of Life and Reproduction Sciences

[13] Institute of Genetics and Biophysics A. Buzzati-Traverso,Department of Psychology

[14] Consiglio Nazionale delle Ricerche (CNR),Department of Cardiology

[15] National Heart,Department of Epidemiology

[16] Lung,Department of Immunology

[17] and Blood Institute's Framingham Heart Study,Department of Internal Medicine

[18] National Heart,Department of Cardiovascular Medicine

[19] Lung,Department of Chronic Disease Prevention

[20] and Blood Institute's Center for Population Studies,Division of Preventive Medicine

[21] Massachusetts General Hospital,Department of Physiology

[22] Estonian Genome Center,Department of Allergy and Rheumatology

[23] University of Tartu,Department of Neurology

[24] Boston University,Department of Cardiovascular Sciences

[25] Clinical Research Branch,Division of Epidemiology and Community Health

[26] National Institute on Aging,Department of Preventive Medicine

[27] University of Lausanne,Department of Epidemiology

[28] Swiss Institute of Bioinformatics,Department of Medicine

[29] Icelandic Heart Association Research Institute,Department of Health Services

[30] Faculty of Medicine,Department of Medicine

[31] University of Iceland,Department of Genomics of Common Disease

[32] University of Maryland School of Medicine,Department of Obstetrics and Gynecology

[33] Erasmus Medical Center,Department of Medicine II

[34] Prince Charles Hospital,Department of Biomedical Engineering

[35] Genetic Epidemiology,Division of Nephrology, Department of Medicine

[36] Queensland Institute of Medical Research,LifeLines Department

[37] Clinical Pharmacology Unit,Department of Epidemiology and Biostatistics

[38] University of Cambridge,Division of Endocrinology and Diabetes, Department of Medicine

[39] University of Alabama at Birmingham,Department of Psychiatry

[40] Birmingham Veterans Affairs Medical Center,Department of Psychiatry

[41] University of Alabama at Birmingham,Department of Psychiatry

[42] Institute for Maternal and Child Health,Department of Medicine

[43] Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo–Trieste,Division of Rheumatology

[44] University of Trieste,Division of Genetics

[45] Cardiovascular Health Research Unit,Division of Experimental Cardiology, Department of Cardiology

[46] University of Washington,Department of Internal Medicine

[47] Faculty of Medicine,Medical Department

[48] University of Split,Department of Chronic Disease Prevention

[49] Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8199,Department of Clinical Physiology

[50] Genomics and Molecular Physiology of Metabolic Diseases,Department of Medicine

来源：

Nature Genetics | 2013年 / 45卷

关键词：

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中图分类号：

学科分类号：

摘要：

Anna Köttgen and colleagues report genome-wide association studies for serum urate in over 140,000 individuals from the Global Urate Genetics Consortium (GUGC). They identify 18 loci newly associated with serum urate concentrations and confirm 10 known loci, characterize their associations with gout and include a network analysis suggesting a role for inhibins-activins pathways in regulating urate homeostasis.

引用

页码：145 / 154

页数：9

共 50 条

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Koettgen, Anna
Albrecht, Eva
Teumer, Alexander
Vitart, Veronique
Krumsiek, Jan
Hundertmark, Claudia
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