Assembly of the Yeast Vacuolar Proton-Translocating ATPase

被引:0
作者
Laurie A. Graham
Tom H. Stevens
机构
[1] University of Oregon,Institute of Molecular Biology
关键词
yeast; V-ATPase; assembly; vacuoles; multisubunit; endoplasmic reticulum; membrane yeast; V-ATPase; assembly; vacuoles; multisubunit; endoplasmic reticulum; membrane proteins; proton-translocating;
D O I
10.1023/A:1005455411918
中图分类号
学科分类号
摘要
The yeast vacuolar proton-translocating ATPase (V-ATPase) is the bestcharacterized member of the V-ATPase family. Biochemical and genetic screensled to the identification of a large number of genes in yeast, designatedVMA, encoding proteins required to assemble a functional V-ATPase. Atotal of thirteen genes encode subunits of the final enzyme complex. Inaddition to subunit-encoding genes, we have identified three genes that codefor proteins that are not part of the final V-ATPase complex yet required forits assembly. We refer to these nonsubunit Vma proteins as assembly factors,since their function is dedicated to assembling the V-ATPase. The assemblyfactors, Vma12p, Vma21p, and Vma22p are localized to the endoplasmicreticulum (ER) and aid the assembly of newly synthesized V-ATPase subunitsthat are translocated into the ER membrane. At least two of these proteins,Vma12p and Vma22p, function together in an assembly complex and interactdirectly with nascent V-ATPase subunits.
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页码:39 / 47
页数:8
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