Recyclization of N-arylitaconimides with carboximidamides – a novel efficient method for the synthesis of 2-(2-amino-6-oxo- 1,4,5,6-tetrahydropyrimidin-5-yl)acetanilides

被引：0
作者：
Nikita M. Sotnikov
Yurii А. Kovygin
Dmitrii Yu. Vandyshev
Irina V. Ledenyova
Yevgeniya А. Kosheleva
Oleg А. Kozadyorov
Khidmet S. Shikhaliev
机构：
[1] Voronezh State University,
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
carboximidamides; dihydropyrimidines; itaconimides; hybrid molecules; recyclization;
D O I：
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学科分类号：
摘要：
A convenient method for the preparation of 2-(2-amino-6-oxo-1,4,5,6-tetrahydropyrimidin-5-yl)acetanilides based on the reaction of N-arylitaconimides with various carboximidamides has been proposed. In the course of the transformation, a cascade reaction occurs encompassing the aza-Michael addition of carboximidamides to N-arylitaconimides and the subsequent recyclization of intermediates to dihydropyrimidine acetanilides.
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页码：154 / 158
页数：4
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