Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

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作者
Ntokozo S. Dambuza
Peter Smith
Alicia Evans
Jennifer Norman
Dale Taylor
Andrew Andayi
Timothy Egan
Kelly Chibale
Lubbe Wiesner
机构
[1] University of Cape Town,Division of Clinical Pharmacology, Department of Medicine
[2] University of Cape Town,Department of Chemistry
来源
Malaria Journal | / 14卷
关键词
Malaria; Pharmacokinetics; Hydroxypyridone-chloroquine; In vivo efficacy;
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[1]  
Prakash A(2013)In vitro and in vivo antiplasmodial activity of the root extracts of Brucea mollis Wall. ex Kurz Parasitol Res 112 637-642
[2]  
Sharma SK(2004)The origins of antimalarial drug resistance Trends Parasitol 20 512-518
[3]  
Mohapatra PK(2011)Clinical practice Eur J Pediatr 170 821-829
[4]  
Bhattacharjee K(1998)Involvement of heme in the antimalarial action of chloroquine Trans Am Clin Climatol Assoc 109 97-105
[5]  
Gogoi K(2004)Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs Life Sci 74 1957-1972
[6]  
Gogoi P(2001)On the mechanism of hemozoin production in malaria parasites: activated erythrocyte membranes promote β-hematin synthesis Exp Biol Med. 226 746-752
[7]  
Hastings IM(2012)Insights into the role of heme in the mechanism of action of antimalarials ACS Chem Biol 8 133-137
[8]  
Maltha J(1994)Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment) FEBS Lett 352 54-57
[9]  
Jacobs J(1999)Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials Biochem J 339 363-370
[10]  
Fitch CD(2012)Antimalarial iron chelator, FBS0701, shows asexual and gametocyte PLoS One 7 e37171-915