Photo-triggered nucleus targeting for cancer drug delivery

被引：0

作者：

Yafei Li

Wen Lv

Lang Wang

Yaming Zhang

Lipeng Yang

Tianyi Wang

Linyong Zhu

Yufeng Wang

Weiping Wang

机构：

[1] The University of Hong Kong,Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine

[2] The University of Hong Kong,Dr. Li Dak

[3] The University of Hong Kong,Sum Research Centre

[4] East China University of Science and Technology,Department of Chemistry

来源：

Nano Research | 2021年 / 14卷

关键词：

phototargeting; dePEGylation; nucleus targeting; coumarin; photoresponsive prodrugs;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Here, we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control. The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs. By incorporating a nucleus localization sequence in the system, drug nanoparticles could be delivered into nuclei upon visible light irradiation. The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability, which efficiently killed cancer cells. This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery. [graphic not available: see fulltext]

引用

页码：2630 / 2636

页数：6