Synthesis of new amidophosphite ligand and its application in Ir-catalyzed asymmetric hydrogenation of heterocyclic compounds

被引：0
作者：
S. E. Lyubimov
D. V. Ozolin
A. A. Pavlov
I. N. Fedorova
V. S. Velezheva
V. A. Davankov
机构：
[1] Russian Academy of Sciences,A. N. Nesmeyanov Institute of Organoelement Compounds
来源：
Russian Chemical Bulletin | 2013年 / 62卷
关键词：
asymmetric hydrogenation; amidophosphite; iridium; heterocyclic compounds;
D O I：
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中图分类号：
学科分类号：
摘要：
A new chiral amidophosphite ligand was synthesized and tested in the iridium-catalyzed hydrogenation of heterocyclic compounds. The enantioselectivity of hydrogenation of 2-methylquinoline considerably increases when piperidine hydrochloride is used as an additive. The hydrogenation reaction of 8-methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole by metal complex was conducted for the first time to prepare enantiomerically enriched antidepressant Pyrazidol.
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页码：1405 / 1408
页数：3
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