Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis

被引：0
作者：
O. Yu. Makarycheva
E. Yu. Tsareva
M. A. Sudomoina
O. G. Kulakova
O. V. Bykova
N. V. Gol’tsova
L. M. Kuzenkova
A. N. Boiko
O. O. Favorova
机构：
[1] Russian Cardiological Research and Production Center,Science Center for Children Health
[2] N.I. Pirogov Russian State Medical University,undefined
[3] Russian Academy of Medical Sciences,undefined
来源：
Molecular Biology | 2010年 / 44卷
关键词：
human; multiple sclerosis; genotyping; proinflammatory cytokines; tumor necrosis factor; inter-leukin-6; interferon-γ; allelic polymorphism; TDT; functional genomics;
D O I：
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学科分类号：
摘要：
Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF*(−308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians.
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页码：728 / 733
页数：5
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