Allergens and thunderstorm asthma

被引：0
作者：
Shuaib M. Nasser
Thomas B. Pulimood
机构：
[1] Cambridge University Hospitals National Health Service Foundation Trust,Department of Allergy
来源：
Current Allergy and Asthma Reports | 2009年 / 9卷
关键词：
Asthma; Fungal Spore; Allergy Clin Immunol; Grass Pollen; Grass Pollen Season;
D O I：
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摘要：
Thunderstorm-related asthma is increasingly recognized in many parts of the world. This review focuses on important advances in the understanding of the mechanism of the role of allergens, in particular fungal spores such as Alternaria, in asthma epidemics associated with thunderstorms. From our observations, we have proposed that the prerequisites for this phenomenon are as follows: 1) a sensitized, atopic, asthmatic individual; 2) prior airway hyperresponsiveness before a sudden, large allergen exposure; 3) a large-scale thunderstorm with cold outflow occurring at a time and location during an allergen season in which large numbers of asthmatics are outdoors; and 4) sudden release of large amounts of respirable allergenic fragments, particularly fungal spores such as Alternaria.
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