Microstructural changes precede depression in patients with relapsing-remitting Multiple Sclerosis

被引：0
作者：
Frank Riemer
Ellen Skorve
Ofer Pasternak
Fulvio Zaccagna
Astri J. Lundervold
Øivind Torkildsen
Kjell-Morten Myhr
Renate Grüner
机构：
[1] Haukeland University Hospital,Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology
[2] Haukeland University Hospital,Neuro
[3] University of Bergen,SysMed, Department of Neurology
[4] Brigham and Women’s Hospital,Department of Clinical Medicine
[5] Harvard Medical School,Department of Psychiatry
[6] Brigham and Women’s Hospital,Department of Radiology
[7] Harvard Medical School,Department of Imaging
[8] Cambridge University Hospitals NHS Foundation Trust,Department of Radiology
[9] Cambridge Biomedical Campus,Investigative Medicine Division
[10] University of Cambridge,Department of Biological and Medical Psychology
[11] Radcliffe Department of Medicine,Department of Physics and Technology
[12] University of Oxford,undefined
[13] University of Bergen,undefined
[14] University of Bergen,undefined
来源：
Communications Medicine | / 3卷
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摘要：
Signals between the brain and spinal cord are disrupted in people with Multiple Sclerosis. For those with relapsing-remitting Multiple Sclerosis (RRMS), symptoms get periodically better and worse over time. We looked at whether changes in the brain of people with RRMS were associated with changes in their mood over time. People who had more changes in certain areas of the brain at the start of the study were more likely to have symptoms of depression later. This work suggests that early changes in the brain may be linked to increased symptoms of depression over time in people with RRMS. We believe this could be an opportunity to provide care to those suffering from RRMS to lessen the impact of severe depression symptoms before they arise.
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