Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

被引：0
作者：
F K Engels
A Sparreboom
R A A Mathot
J Verweij
机构：
[1] Erasmus MC - Daniel den Hoed Cancer Center Rotterdam,Department of Medical Oncology
[2] Clinical Pharmacology Research Core,Department of Hospital Pharmacy and Clinical Pharmacology
[3] Medical Oncology Clinical Research Unit,undefined
[4] National Cancer Institute,undefined
[5] Erasmus MC,undefined
来源：
British Journal of Cancer | 2005年 / 93卷
关键词：
docetaxel; taxotere; taxanes; pharmacology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.
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页码：173 / 177
页数：4
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