Kinetics and mechanism of the reaction between aquacobalamin and isoniazid

被引：0
作者：
S. O. Tumakov
I. A. Dereven’kov
D. S. Salnikov
S. V. Makarov
机构：
[1] Ivanovo State University of Chemistry and Technology,
来源：
Russian Journal of Physical Chemistry A | 2017年 / 91卷
关键词：
mechanism of reaction; kinetics; cobalamin; isoniazid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Kinetics of the reaction of aquacobalamin (H2OCbl) with isoniazid (isonicotinic acid hydrazide, INH) in weakly alkaline, neutral, and weakly acidic media was studied using UV–Vis spectroscopy. It is shown that the reversible formation of a complex more stable than those of cobalamin(III) with pyridine and hydrazine occurs during the reaction. A mechanism of the reaction includes reversible stages of binding a neutral INH molecule by cobalamin(III) through an oxygen atom with its subsequent deprotonation, along with the reversible interaction of H2OCbl and the negatively charged form of INH.
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页码：1839 / 1844
页数：5
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