Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients

被引:0
作者
J A Foekens
M P Look
J Bolt-de Vries
M E Meijer-van Gelder
W L J van Putten
J G M Klijn
机构
[1] Rotterdam Cancer Institute (Daniel den Hoed Kliniek),Division of Endocrine Oncology, Department of Medical Oncology
[2] Academic Hospital Rotterdam,Department of Statistics
[3] Rotterdam Cancer Institute (Daniel den Hoed Kliniek),undefined
[4] Academic Hospital Rotterdam,undefined
来源
British Journal of Cancer | 1999年 / 79卷
关键词
cathepsin-D; breast cancer; breast cancer prognosis; multivariate analysis;
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摘要
There is controversy regarding the prognostic value of cathepsin-D in primary breast cancer. An increased level of cathepsin-D in tumour extracts has been found to be associated with a poor relapse-free and overall survival. Studies performed with immunohistochemistry or Western blotting have produced diverse results. We have analysed 2810 cytosolic extracts obtained from human primary breast tumours for cathepsin-D expression, and have correlated their levels with prognosis. The median follow-up of the patients still alive was 88 months. Patients with high cathepsin-D levels had a significantly worse relapse-free and overall survival, also in multivariate analysis (P < 0.0001). Adjuvant therapy which was associated with an improved prognosis in node-positive patients in univariate analysis, also significantly added to the multivariate models for relapse-free and overall survival. There were no statistically significant interactions between the levels of cathepsin-D and any of the classical prognostic factors in analysis for relapse-free survival, suggesting that the prognostic value of cathepsin-D is not different in the various subgroups of patients. Indeed, multivariate analyses in subgroups of node-negative and -positive patients, pre- and post-menopausal patients, and their combinations, showed that tumours with high cathepsin-D values had a significantly poor relapse-free survival, with relative hazard rates ranging from 1.3 to 1.5, compared with tumours with low cathepsin-D levels. The results presented here on 2810 patients confirm that high cytosolic cathepsin-D values are associated with poor prognosis in human primary breast cancer.
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页码:300 / 307
页数:7
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