Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

被引：0
|
作者：
Edward Sausville
Patricia LoRusso
Michael Carducci
Judith Carter
Mary F. Quinn
Lisa Malburg
Nilofer Azad
David Cosgrove
Richard Knight
Peter Barker
Sonya Zabludoff
Felix Agbo
Patricia Oakes
Adrian Senderowicz
机构：
[1] University of Maryland,Marlene and Stewart Greenebaum Cancer Center
[2] Wayne State University School of Medicine,Karmanos Cancer Center
[3] Johns Hopkins Medical Institutions,Sidney Kimmel Comprehensive Cancer Center
[4] AstraZeneca,undefined
来源：
Cancer Chemotherapy and Pharmacology | 2014年 / 73卷
关键词：
AZD7762; Chk1; Solid tumors; Phase I; Safety; Pharmacokinetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：539 / 549
页数：10
相关论文
共 50 条
  • [1] Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
    Sausville, Edward
    LoRusso, Patricia
    Carducci, Michael
    Carter, Judith
    Quinn, Mary F.
    Malburg, Lisa
    Azad, Nilofer
    Cosgrove, David
    Knight, Richard
    Barker, Peter
    Zabludoff, Sonya
    Agbo, Felix
    Oakes, Patricia
    Senderowicz, Adrian
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 73 (03) : 539 - 549
  • [2] Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours
    Seto, Takashi
    Esaki, Taito
    Hirai, Fumihiko
    Arita, Shuji
    Nosaki, Kaname
    Makiyama, Akitaka
    Kometani, Takuro
    Fujimoto, Chinatsu
    Hamatake, Motoharu
    Takeoka, Hiroaki
    Agbo, Felix
    Shi, Xiaojin
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 72 (03) : 619 - 627
  • [3] Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours
    Takashi Seto
    Taito Esaki
    Fumihiko Hirai
    Shuji Arita
    Kaname Nosaki
    Akitaka Makiyama
    Takuro Kometani
    Chinatsu Fujimoto
    Motoharu Hamatake
    Hiroaki Takeoka
    Felix Agbo
    Xiaojin Shi
    Cancer Chemotherapy and Pharmacology, 2013, 72 : 619 - 627
  • [4] Phase I dose-escalation study of cabazitaxel administered in combination with cisplatin in patients with advanced solid tumors
    A. Craig Lockhart
    Shankar Sundaram
    John Sarantopoulos
    Monica M. Mita
    Andrea Wang-Gillam
    Jennifer L. Moseley
    Stephanie L. Barber
    Alex R. Lane
    Claudine Wack
    Laurent Kassalow
    Jean-François Dedieu
    Alain C. Mita
    Investigational New Drugs, 2014, 32 : 1236 - 1245
  • [5] Phase I dose-escalation study of cabazitaxel administered in combination with cisplatin in patients with advanced solid tumors
    Lockhart, A. Craig
    Sundaram, Shankar
    Sarantopoulos, John
    Mita, Monica M.
    Wang-Gillam, Andrea
    Moseley, Jennifer L.
    Barber, Stephanie L.
    Lane, Alex R.
    Wack, Claudine
    Kassalow, Laurent
    Dedieu, Jean-Francois
    Mita, Alain C.
    INVESTIGATIONAL NEW DRUGS, 2014, 32 (06) : 1236 - 1245
  • [6] Sunitinib in combination with docetaxel in patients with advanced solid tumors: a phase I dose-escalation study
    Robert, Francisco
    Sandler, Alan
    Schiller, Joan H.
    Liu, Glenn
    Harper, Karen
    Verkh, Lev
    Huang, Xin
    Ilagan, Jennifer
    Tye, Lesley
    Chao, Richard
    Traynor, Anne M.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2010, 66 (04) : 669 - 680
  • [7] Sunitinib in combination with docetaxel in patients with advanced solid tumors: a phase I dose-escalation study
    Francisco Robert
    Alan Sandler
    Joan H. Schiller
    Glenn Liu
    Karen Harper
    Lev Verkh
    Xin Huang
    Jennifer Ilagan
    Lesley Tye
    Richard Chao
    Anne M. Traynor
    Cancer Chemotherapy and Pharmacology, 2010, 66 : 669 - 680
  • [8] A dose-escalation and pharmacokinetic study of gemcitabine and oxaliplatin in patients with advanced solid tumors
    Mavroudis, D
    Pappas, P
    Kouroussis, C
    Kakolyris, S
    Agelaki, S
    Kalbakis, K
    Androulakis, N
    Souglakos, J
    Vardakis, N
    Nikolaidou, M
    Samonis, G
    Marselos, M
    Georgoulias, V
    ANNALS OF ONCOLOGY, 2003, 14 (02) : 304 - 312
  • [9] Phase I Dose-Escalation Study of Ramucirumab in Chinese Patients with Advanced Solid Tumors
    Cao, Junning
    Ji, Dongmei
    Chen, Zhiyu
    Shen, Weina
    Wang, Jin
    Li, Baoyue
    Chi, Haidong
    Long, Amanda
    Gao, Ling
    Li, Jin
    ONCOLOGIST, 2017, 22 (06): : 638 - +
  • [10] Phase I dose-escalation study of cabazitaxel administered in combination with gemcitabine in patients with metastatic or unresectable advanced solid malignancies
    Rixe, Olivier
    Puzanov, Igor
    LoRusso, Patricia M.
    Cohen, Roger B.
    Morris, John C.
    Olowokure, Olugbenga O.
    Yin, Jian Y.
    Doroumian, Severine
    Shen, Liji
    Olszanski, Anthony J.
    ANTI-CANCER DRUGS, 2015, 26 (07) : 785 - 792
12345