DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

被引：0

作者：

Atsushi Niida

Takatoshi Hiroko

Mana Kasai

Yoichi Furukawa

Yusuke Nakamura

Yutaka Suzuki

Sumio Sugano

Tetsu Akiyama

机构：

[1] Laboratory of Molecular and Genetic Information,

[2] Institute of Molecular and Cellular Biosciences,undefined

[3] The University of Tokyo,undefined

[4] 1-1-1 Yayoi,undefined

[5] Bunkyo-ku,undefined

[6] Laboratory of Molecular Medicine,undefined

[7] Human Genome Center,undefined

[8] Institute of Medical Science,undefined

[9] The University of Tokyo,undefined

[10] 4-6-1 Shirokane-dai,undefined

[11] Minato-ku,undefined

[12] Laboratory of Genome Database,undefined

[13] Human Genome Center,undefined

[14] Institute of Medical Science,undefined

[15] The University of Tokyo,undefined

[16] 4-6-1 Shirokanedai,undefined

[17] Minato-ku,undefined

来源：

Oncogene | 2004年 / 23卷

关键词：

DKK1; Wnt; -catenin; TCF; TCF-binding element; negative feedback;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the β-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.

引用

页码：8520 / 8526

页数：6