Putting More Weight on Obesity Trials in Heart Failure

被引：1
作者：
Harrington, Josephine [1 ,2 ]
Sattar, Naveed [3 ]
Felker, G. Michael [1 ,2 ]
Januzzi, James L. [4 ,5 ]
Lam, Carolyn S. P. [5 ,6 ,7 ]
Pagidipati, Neha J. [1 ,2 ]
Pandey, Ambarish [8 ]
Van Spall, Harriette G. C. [4 ,9 ,10 ]
McGuire, Darren K. [8 ,11 ]
机构：
[1] Duke Univ, Med Ctr, Dept Internal Med, Div Cardiol, Durham, NC 27710 USA
[2] Duke Clin Res Inst, 300 W Morgan St, Durham, NC 27701 USA
[3] Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland
[4] Baim Inst Clin Res, Boston, MA USA
[5] Massachusetts Gen Hosp, Harvard Med Sch, Cardiol Div, Boston, MA USA
[6] Natl Heart Ctr Singapore, Singapore, Singapore
[7] Duke Natl Univ Singapore, Singapore, Singapore
[8] Univ Texas SouthWestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX USA
[9] Res Inst St Joes, Hamilton, ON, Canada
[10] McMaster Univ, Hamilton, ON, Canada
[11] Parkland Hlth & Hosp Syst, Dallas, TX USA
来源：
CURRENT HEART FAILURE REPORTS | 2024年 / 21卷 / 03期
关键词：
Heart failure; Obesity; Weight loss; Clinical trial; BODY-MASS INDEX; BARIATRIC SURGERY; RISK-FACTORS; MORTALITY; REDUCTION; LIRAGLUTIDE; SEMAGLUTIDE; MECHANISMS; OVERWEIGHT; OUTCOMES;
D O I：
10.1007/s11897-024-00655-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of ReviewTo review ongoing and planned clinical trials of weight loss among individuals with or at high risk of heart failure.Recent FindingsIntentional weight loss via semaglutide among persons with heart failure and preserved ejection fraction and obesity significantly improves weight loss and health status as assessed by the KCCQ-CSS score and is associated with improvements in 6-min walk test.SummaryOngoing and planned trials will explore the role of intentional weight loss with treatments such as semaglutide or tirzepatide for individuals with heart failure across the entire ejection fraction spectrum.
引用
收藏
页码：194 / 202
页数：9
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