Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation

被引：0
|
作者：
Maryam Tahvildari
Afsaneh Amouzegar
William Foulsham
Reza Dana
机构：
[1] Harvard Medical School,Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary
[2] Wayne State University,Kresge Eye Institute
来源：
Cellular and Molecular Life Sciences | 2018年 / 75卷
关键词：
Corneal transplantation; Graft rejection; Allotolerance; Regulatory T cells; Antigen presenting cells; Corneal hemangiogenesis; Corneal lymphangiogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.
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页码：1509 / 1520
页数：11
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