PI3K/Akt: getting it right matters

被引：0
作者：
T F Franke
机构：
[1] New York University School of Medicine,Departments of Psychiatry and Pharmacology
来源：
Oncogene | 2008年 / 27卷
关键词：
Akt/PKB; PI3K/PTEN; PDK2; mTORC; Akt-interacting proteins; human disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.
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页码：6473 / 6488
页数：15
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