Mobile elements and the human genome

被引:0
作者
Luning Prak E.T. [1 ]
Kazazian Jr. H.H. [1 ]
机构
[1] Department of Genetics, 475 Clinical Research Building, University of Pennsylvania, Philadelphia, PA 19104
关键词
D O I
10.1038/35038572
中图分类号
学科分类号
摘要
Genomic DNA is often thought of as the stable template of heredity, largely dormant and unchanging, apart from perhaps the occasional point mutation. But it has become increasingly clear that DNA is dynamic rather than static, being subjected to rearrangements, insertions and deletions. Much of this plasticity can be attributed to transposable elements and their genomic relatives.
引用
收藏
页码:134 / 144
页数:10
相关论文
共 50 条
[41]   Meeting report: mobile genetic elements and genome plasticity 2018 [J].
John M. Abrams ;
Irina R. Arkhipova ;
Marlene Belfort ;
Jef D. Boeke ;
M. Joan Curcio ;
Geoffrey J. Faulkner ;
John L. Goodier ;
Ruth Lehmann ;
Henry L. Levin .
Mobile DNA, 9
[42]   Editorial overview: Genome architecture and expression: Mobile elements at work [J].
Lisch, Damon ;
Burns, Kathleen H. .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2018, 49 :IV-V
[43]   Meeting report: mobile genetic elements and genome plasticity 2018 [J].
Abrams, John M. ;
Arkhipova, Irina R. ;
Belfort, Marlene ;
Boeke, Jef D. ;
Curcio, M. Joan ;
Faulkner, Geoffrey J. ;
Goodier, John L. ;
Lehmann, Ruth ;
Levin, Henry L. .
MOBILE DNA, 2018, 9
[44]   From the margins of the genome: mobile elements shape primate evolution [J].
Hedges, DJ ;
Batzer, MA .
BIOESSAYS, 2005, 27 (08) :785-794
[45]   Mobile genetic elements in Clostridium difficile and their role in genome function [J].
Mullany, Peter ;
Allan, Elaine ;
Roberts, Adam P. .
RESEARCH IN MICROBIOLOGY, 2015, 166 (04) :361-367
[46]   Ancient noncoding elements conserved in the human genome [J].
Venkatesh, Byrappa ;
Kirkness, Ewen F. ;
Loh, Yong-Hwee ;
Halpern, Aaron L. ;
Lee, Alison P. ;
Johnson, Justin ;
Dandona, Nidhi ;
Viswanathan, Lakshmi D. ;
Tay, Alice ;
Venter, J. Craig ;
Strausberg, Robert L. ;
Brenner, Sydney .
SCIENCE, 2006, 314 (5807) :1892-1892
[47]   An integrated encyclopedia of DNA elements in the human genome [J].
Dunham, Ian ;
Kundaje, Anshul ;
Aldred, Shelley F. ;
Collins, Patrick J. ;
Davis, CarrieA. ;
Doyle, Francis ;
Epstein, Charles B. ;
Frietze, Seth ;
Harrow, Jennifer ;
Kaul, Rajinder ;
Khatun, Jainab ;
Lajoie, Bryan R. ;
Landt, Stephen G. ;
Lee, Bum-Kyu ;
Pauli, Florencia ;
Rosenbloom, Kate R. ;
Sabo, Peter ;
Safi, Alexias ;
Sanyal, Amartya ;
Shoresh, Noam ;
Simon, Jeremy M. ;
Song, Lingyun ;
Trinklein, Nathan D. ;
Altshuler, Robert C. ;
Birney, Ewan ;
Brown, James B. ;
Cheng, Chao ;
Djebali, Sarah ;
Dong, Xianjun ;
Dunham, Ian ;
Ernst, Jason ;
Furey, Terrence S. ;
Gerstein, Mark ;
Giardine, Belinda ;
Greven, Melissa ;
Hardison, Ross C. ;
Harris, Robert S. ;
Herrero, Javier ;
Hoffman, Michael M. ;
Iyer, Sowmya ;
Kellis, Manolis ;
Khatun, Jainab ;
Kheradpour, Pouya ;
Kundaje, Anshul ;
Lassmann, Timo ;
Li, Qunhua ;
Lin, Xinying ;
Marinov, Georgi K. ;
Merkel, Angelika ;
Mortazavi, Ali .
NATURE, 2012, 489 (7414) :57-74
[48]   Finding distal regulatory elements in the human genome [J].
Heintzman, Nathaniel D. ;
Ren, Bing .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2009, 19 (06) :541-549
[49]   Identification of transcribed Alu elements in the human genome [J].
Conti, A. ;
Carnevali, D. ;
Dieci, G. .
FEBS JOURNAL, 2014, 281 :393-393
[50]   Genetic Variations of Ultraconserved Elements in the Human Genome [J].
Habic, Anamarija ;
Mattick, John S. ;
Calin, George Adrian ;
Krese, Rok ;
Konc, Janez ;
Kunej, Tanja .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2019, 23 (11) :549-559