Food-grade xylitol production from corncob biomass with acute oral toxicity studies

被引：0

作者：

Diptarka Dasgupta

Vishal Ahuja

Raghuvir Singh

Snehal More

Sandeep Mudliar

Madan Kumar

机构：

[1] CSIR-Indian Institute of Petroleum (CSIR-IIP),Biochemistry & Biotechnology Area

[2] Academy of Scientific & Industrial Research (AcSIR),Analytical Sciences Division

[3] CSIR-Indian Institute of Petroleum,Biochemical Sciences Division

[4] CSIR-Indian Institute of Petroleum,Department Of Plant Cell Biotechnology

[5] CSIR-National Chemical Laboratory (CSIR-NCL),Department of Biochemistry

[6] CSIR-Central Food Technology Research Institute,undefined

[7] CSIR-Central Food Technology Research Institute (CSIR-CFTRI),undefined

来源：

World Journal of Microbiology and Biotechnology | 2023年 / 39卷

关键词：

Xylitol; Corncob; Fermentation; Acute oral toxicity; Shelf life analysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Xylitol, a sugar substitute, is widely used in various food formulations and finds a steady global market. In this study, xylitol crystals were produced from corncob by fermentation (as an alternative to the chemical catalytic process) by a GRAS yeast Pichia caribbica MTCC 5703 and characterized in detail for their purity and presence of any possible contaminant that may adversely affect mammalian cell growth and proliferation. The acute and chronic oral toxicity trials demonstrated no gross pathological changes with average weekly weight gain in female Wistar rats at high xylitol loading (LD50 > 10,000 mg/kg body weight). The clinical chemistry analysis supported the evidence of no dose-dependent effect by analyzing blood biochemical parameters. The finding suggests the possible application of the crystals (> 98% purity) as a food-grade ingredient for commercial manufacture pending human trials.

引用

共 145 条

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