Increased risk of second malignancies inchronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

被引：35
作者：
Beiggi, S. [1 ,2 ]
Johnston, J. B. [2 ,3 ,4 ]
Seftel, M. D. [3 ,4 ]
Pitz, M. W. [3 ,4 ]
Kumar, R. [3 ,4 ]
Banerji, V. [1 ,2 ,3 ,4 ]
Griffith, E. J. [5 ,6 ,7 ]
Gibson, S. B. [1 ,2 ]
机构：
[1] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3E 0V9, Canada
[2] CancerCare Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada
[3] CancerCare Manitoba, Dept Hematol & Med Oncol, Winnipeg, MB R3E 0V9, Canada
[4] Univ Manitoba, Dept Internal Med, Winnipeg, MB R3E 2N2, Canada
[5] Univ Manitoba, Dept Community Hlth Sci, Winnipeg, MB R3E 0W3, Canada
[6] CancerCare Manitoba, Dept Epidemiol, Winnipeg, MB R3E 0V9, Canada
[7] CancerCare Manitoba, Canc Registry, Winnipeg, MB R3E 0V9, Canada
来源：
BRITISH JOURNAL OF CANCER | 2013年 / 109卷 / 05期
关键词：
chronic lymphocytic leukaemia; follicular lymphoma; epidemiology; second malignancies; non-melanoma skin cancers; treatment; NONMELANOMA SKIN-CANCER; DIAGNOSIS; GUIDELINES;
D O I：
10.1038/bjc.2013.381
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Chronic lymphocytic leukaemia (CLL) patients have an increased risk of other malignancies. This may be due to surveillance bias, treatment or immunosuppression. Methods: Cohort study of 612 consecutively diagnosed CLL patients in a Canadian province, with comparisons to follicular lymphoma (FL) patients. Results: Treated CLL patients had a 1.7-fold increased risk of second cancers compared with untreated CLL patients. As compared with untreated FL patients, untreated CLL patients had a two-fold increased incidence of second malignancies. Conclusion: Chronic lymphocytic leukaemia patients have an inherent predisposition to second cancers and the incidence is further increased by treatment.
引用
收藏
页码：1287 / 1290
页数：4
相关论文
共 22 条
[1]   Risk Factors for Non-melanoma Skin Cancer in Kidney Transplant Patients in a Spanish Population in the Mediterranean Region [J].
Bernat Garcia, Josefa ;
Morales Suarez-Varela, Maria ;
Vilata, Juan J. ;
Marquina, Amparo ;
Pallardo, Luis ;
Crespo, Josep .
ACTA DERMATO-VENEREOLOGICA, 2013, 93 (04) :422-427
[2]   Non-melanoma skin cancer: carcinogenesis and chemoprevention [J].
Chen, Andrew C. ;
Halliday, Gary M. ;
Damian, Diona L. .
PATHOLOGY, 2013, 45 (03) :331-341
[3]   National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment [J].
Cheson, BD ;
Bennett, JM ;
Grever, M ;
Kay, N ;
Keating, MJ ;
OBrien, S ;
Rai, KR .
BLOOD, 1996, 87 (12) :4990-4997
[4]   A proportional hazards model for the subdistribution of a competing risk [J].
Fine, JP ;
Gray, RJ .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1999, 94 (446) :496-509
[5]  
GREENE MH, 1978, JNCI-J NATL CANCER I, V61, P337
[6]   Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia:: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines [J].
Hallek, Michael ;
Cheson, Bruce D. ;
Catovsky, Daniel ;
Caligaris-Cappio, Federico ;
Dighiero, Guillaume ;
Doehner, Hartmut ;
Hillmen, Peter ;
Keating, Michael J. ;
Montserrat, Emili ;
Rai, Kanti R. ;
Kipps, Thomas J. .
BLOOD, 2008, 111 (12) :5446-5456
[7]  
Johnston JB, 2009, WINTROBES CLIN HEMAT, P2256
[8]   FAMILIAL CANCER HISTORY AND CHRONIC LYMPHOCYTIC-LEUKEMIA - A CASE-CONTROL STUDY [J].
LINET, MS ;
VANNATTA, ML ;
BROOKMEYER, R ;
KHOURY, MJ ;
MCCAFFREY, LD ;
HUMPHREY, RL ;
SZKLO, M .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 130 (04) :655-664
[9]   SUBSEQUENT NEOPLASIA IN CHRONIC LYMPHOCYTIC LEUKEMIA [J].
MANUSOW, D ;
WEINERMAN, BH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 232 (03) :267-269
[10]   Second neoplasms in chronic lymphocytic leukemia: incidence and pathogenesis with emphasis on the role of different therapies [J].
Molica, S .
LEUKEMIA & LYMPHOMA, 2005, 46 (01) :49-54
123