Successful chelation therapy in a case of neonatal iron overload following intravascular intrauterine transfusion

被引：0

作者：

Sreenan C. ^{[1
,2
,4
]}

Idikio H.A. ^{[3
]}

Osiovich H. ^{[1
,2
]}

机构：

[1] Neonatal Intensive Care Unit, University of Alberta Hospital

[2] Department of Pediatrics, University of Alberta, Edmonton, Alta.

[3] Department of Pathology, University of Alberta, Edmonton, Alta.

[4] Neonatal Intensive Care Unit, Royal Alexandra Hospital, Edmonton, Alta. T5H 3V9

来源：

Journal of Perinatology | 2000年 / 20卷 / 8期

关键词：

D O I：

10.1038/sj.jp.7200458

中图分类号：

学科分类号：

摘要：

OBJECTIVE: We report a newborn infant who was successfully treated with chelation therapy having developed severe liver disease secondary to iron overload following multiple intrauterine, intravascular transfusions (IVTs). STUDY DESIGN: Case report with review of the literature. RESULTS: An infant was born at 33 weeks' gestation having received multiple IVTs for severe rhesus hemolytic disease. At birth there was severe anemia with hydrops and ascites. Severe liver disease was present with portal hypertension, coagulopathy and abnormal liver enzymes. A liver biopsy showed histologic features consistent with iron overload. The serum ferritin was in excess of 4000 μg/1. A 7-week course of deferoxamine resulted in a marked reduction in ferritin levels and significant improvement in liver function. CONCLUSION: The possibility of neonatal iron overload following multiple IVTs should be borne in mind. Successful chelation therapy is possible in such cases.

引用

页码：509 / 512

页数：3

共 11 条

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