Recent advance of pH-sensitive nanocarriers targeting solid tumors

被引：41
作者：
Sim T. [1 ]
Lim C. [1 ]
Hoang N.H. [2 ]
Oh K.T. [1 ]
机构：
[1] College of Pharmacy, Chung-Ang University, 84 Heukseok-Ro, Dongjak-gu, Seoul
[2] Department of Pharmaceutics, Ha Noi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi
来源：
Journal of Pharmaceutical Investigation | 2017年 / 47卷 / 5期
基金：
新加坡国家研究基金会;
关键词：
Cancer; Drug delivery; Morphology; pH-sensitive nanocarrier; Poly(amino acid);
D O I：
10.1007/s40005-017-0349-1
中图分类号：
学科分类号：
摘要：
pH sensitive nanocarriers have showed the tumor targeted drug delivery and release by enhanced permeability and retention effect and responsiveness of acidic pH conditions of the solid tumors. The protonation and deprotonation of the nanocarriers including pH sensitive polyelectrolytes has been considered as a major mechanism, resulting in substantial conformational change in response to marginal change in the tumor pH conditions. Considering the biocompatible properties for pharmaceutical applications, poly(amino acid) showed low polymer toxicity and the formation of versatile systems for advanced antitumor therapeutic effects. In here, recent researches using cationic (histidine, lysine, and arginine), anionic (aspartic acid and glutamic acid), and zwitterionic amino acid were summarized. Furthermore, pH sensitive nanogels with unique functionality and other pH sensitive polymers were briefly described. pH sensitive nanogels showed reversible drug release by pH cyclization minimizing drug loss and enhancing drug release. In the future, non-spherical pH sensitive nanocarriers would be anticipated to improve the therapeutic effect by long circulation and stealth effect by low phagocytosis. © 2017, The Korean Society of Pharmaceutical Sciences and Technology.
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收藏
页码：383 / 394
页数：11
相关论文
共 143 条
[1]  
Ahmad Z., Tang Z., Shah A., Lv S., Zhang D., Zhang Y., Chen X., Cisplatin loaded methoxy poly (ethylene glycol)-block-Poly (l-glutamic acid-co-l-phenylalanine) nanoparticles against human breast cancer cell, Macromol Biosci, 14, pp. 1337-1345, (2014)
[2]  
Ahmad Z., Lv S., Tang Z., Shah A., Chen X., Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole) hexyl amine nanoparticles for potential hypoxia-responsive delivery of doxorubicin, J Biomater Sci Polym Ed, 27, pp. 40-54, (2016)
[3]  
Ahn J., Miura Y., Yamada N., Chida T., Liu X., Kim A., Sato R., Tsumura R., Koga Y., Yasunaga M., Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer, Biomaterials, 39, pp. 23-30, (2015)
[4]  
Al-Jamal K.T., Al-Jamal W.T., Wang J.T.W., Rubio N., Buddle J., Gathercole D., Zloh M., Kostarelos K., Cationic poly-l-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo, ACS Nano, 7, pp. 1905-1917, (2013)
[5]  
Allen C., Maysinger D., Eisenberg A., Nano-engineering block copolymer aggregates for drug delivery, Colloids Surf B, 16, pp. 3-27, (1999)
[6]  
Bae Y., Kataoka K., Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers, Adv Drug Delivery Rev, 61, pp. 768-784, (2009)
[7]  
Baumhover N.J., Duskey J.T., Khargharia S., White C.W., Crowley S.T., Allen R.J., Rice K.G., Structure-activity relationship of PEGylated polylysine peptides as scavenger receptor inhibitors for non-viral gene delivery, Mol Pharm, 12, pp. 4321-4328, (2015)
[8]  
Borrajo E., Abellan-Pose R., Soto A., Garcia-Fuentes M., Csaba N., Alonso M.J., Vidal A., Docetaxel-loaded polyglutamic acid-PEG nanocapsules for the treatment of metastatic cancer, J Controlled Release, 238, pp. 263-271, (2016)
[9]  
Cabane E., Zhang X., Langowska K., Palivan C.G., Meier W., Stimuli-responsive polymers and their applications in nanomedicine, Biointerphases, 7, (2012)
[10]  
Chen C.-K., Jones C.H., Mistriotis P., Yu Y., Ma X., Ravikrishnan A., Jiang M., Andreadis S.T., Pfeifer B.A., Cheng C., Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery, Biomaterials, 34, pp. 9688-9699, (2013)
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