An integrative investigation on significant mutations and their down-stream pathways in lung squamous cell carcinoma reveals CUL3/KEAP1/NRF2 relevant subtypes

被引:0
作者
Zongang Liu
Meiyan Deng
Lin Wu
Suning Zhang
机构
[1] Department of Thoracic Surgery,
[2] Shengjing Hospital of China Medical University,undefined
来源
Molecular Medicine | 2020年 / 26卷
关键词
Lung squamous cell carcinoma; Down-stream pathways; Prognosis; Subtypes;
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[1]  
Bendavit G(2016)Nrf2 transcription factor can directly regulate mTOR: LINKING CYTOPROTECTIVE GENE EXPRESSION TO a MAJOR METABOLIC REGULATOR THAT GENERATES REDOX ACTIVITY J Biol Chem 291 25476-25488
[2]  
Aboulkassim T(2016)AXL-associated tumor inflammation as a poor prognostic signature in chemotherapy-treated triple-negative breast cancer patients Npj Breast Cancer 2 16033-717
[3]  
Hilmi K(2013)The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation Biochem Pharmacol 85 705-525
[4]  
Shah S(2012)Comprehensive genomic characterization of squamous cell lung cancers Nature. 489 519-1120
[5]  
Batist G(2013)The Cancer Genome Atlas pan-Cancer analysis project Nat Genet 45 1113-89
[6]  
Bottai G(2018)Platelet-derived growth factor receptor-alpha and -beta promote cancer stem cell phenotypes in sarcomas Oncogenesis. 7 47-898
[7]  
Raschioni C(2017)Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function Ann Oncol 28 83-532
[8]  
Székely B(2019)NRF2 Activation in Cancer: From DNA to Protein Cancer Res 79 889-40141
[9]  
Di Tommaso L(2015)Treatment of advanced squamous cell carcinoma of the lung: a review Transl Lung Cancer Res 4 524-1519
[10]  
Szász AM(2000)Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene J Biol Chem 275 40134-DD83