Impact of Coagulation Factors on the Properties of Fibrin Adsorption Films

被引:0
作者
Milyaeva, O. Yu. [1 ]
Rafikova, A. R. [1 ]
机构
[1] St Petersburg State Univ, Inst Chem, St Petersburg 198504, Russia
基金
俄罗斯科学基金会;
关键词
dynamic surface elasticity; surface tension; coagulation factors; fibrinogen; fibrin; thrombin; hemostatic glue; DYNAMIC SURFACE-PROPERTIES; INTERFACES; AIR/WATER; RHEOLOGY; PROTEINS; THROMBIN;
D O I
10.1134/S1061933X24600052
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The formation of a fibrin film at the sites of cuts and wounds is a complex biochemical process that involves fibrinogen and thrombin as the main components, as well as other enzymes and proteins. Dynamic surface properties of adsorption films obtained from the solution, which contains factors VIII, XIIIa, von Willebrand factor and fibronectin, differ from the fibrinogen adsorption films and fibrin films obtained from a solution containing only fibrinogen and thrombin. Their dynamic surface elasticities exceed the corresponding values for fibrinogen (80 and 55 mN/m, respectively); however, they appear to be lower than value for fibrin prepared from pure components (115 mN/m). The surface pressures achieved for the adsorption films obtained from hemostatic glue (27 mN/m) exceed those for both aforementioned systems (14 mN/m). As follows from the Brewster angle microscopy and scanning electron microscopy data, significant changes in the morphology of the resulting films are responsible for the observed effect.
引用
收藏
页码:258 / 266
页数:9
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