共 289 条
[1]
Ross CA(2014)Huntington disease: natural history, biomarkers and prospects for therapeutics Nat Rev Neurol 10 204-216
[2]
Aylward EH(1993)A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes Cell 72 971-983
[3]
Wild EJ(1995)Inactivation of the mouse Huntington’s disease gene homolog Hdh Science 269 407-410
[4]
Langbehn DR(1995)Targeted disruption of the Huntington’s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes Cell 81 811-823
[5]
Long JD(1996)Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats Am J Hum Genet 59 16-22
[6]
Warner JH(1997)Aggregation of Huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain Science 277 1990-1993
[7]
MacDonald ME(1993)The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington’s disease Nat Genet 4 398-403
[8]
Ambrose CM(1996)Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice Cell 87 493-506
[9]
Duyao MP(1988)Differential loss of striatal projection neurons in Huntington disease Proc Natl Acad Sci U S A 85 5733-5737
[10]
Myers RH(2012)Huntington’s disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease Neurotherapeutics 9 270-284