Involvement of linear polyubiquitylation of NEMO in NF-κB activation

被引：0

作者：

Fuminori Tokunaga

Shin-ichi Sakata

Yasushi Saeki

Yoshinori Satomi

Takayoshi Kirisako

Kiyoko Kamei

Tomoko Nakagawa

Michiko Kato

Shigeo Murata

Shoji Yamaoka

Masahiro Yamamoto

Shizuo Akira

Toshifumi Takao

Keiji Tanaka

Kazuhiro Iwai

机构：

[1] Graduate School of Medicine and Cell Biology and Metabolism Group,Department of Biophysics and Biochemistry

[2] Graduate School of Frontier Biosciences,Department of Molecular Cell Biology

[3] Osaka University,Department of Molecular Virology

[4] CREST,Department of Microbiology and Immunology

[5] Japan Science Technology Corporation,undefined

[6] Graduate School of Medicine,undefined

[7] Osaka City University,undefined

[8] Laboratory of Frontier Science,undefined

[9] Core Technology and Research Center,undefined

[10] Tokyo Metropolitan Institute of Medical Science,undefined

[11] Laboratory of Protein Profiling and Functional Proteomics,undefined

[12] Institute for Protein Research,undefined

[13] Osaka University,undefined

[14] Laboratory of Protein Metabolism,undefined

[15] Graduate School of Pharmaceutical Sciences,undefined

[16] The University of Tokyo,undefined

[17] Graduate School of Medicine,undefined

[18] Tokyo Medical and Dental University,undefined

[19] Laboratory of Immune Regulation,undefined

[20] Graduate School of Medicine,undefined

[21] Laboratory of Host Defense,undefined

[22] WPI Immunology Frontier Research Center,undefined

[23] Osaka University,undefined

来源：

Nature Cell Biology | 2009年 / 11卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

NF-κB signalling protein NEMO is the first physiological substrate for linear head-to-tail polyubiquitin chains. The heterodimeric ubiquitin ligase LUBAC catalyses the reaction and mice lacking a LUBAC subunit show defects in NF-κB signalling.

引用

页码：123 / 132

页数：9

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