Overexpression of phosphorylated 4E-binding protein 1 predicts lymph node metastasis and poor prognosis of Chinese patients with hilar cholangiocarcinoma

被引：0
作者：
Zheng Fang
Lei Lu
Zhiqiang Tian
Kunlun Luo
机构：
[1] 101st Hospital of People’s Liberation Army,Department of General Surgery
[2] 81st Hospital of People’s Liberation Army,Department of Oncological Surgery
来源：
Medical Oncology | 2014年 / 31卷
关键词：
Hilar cholangiocarcinoma (HCCA); P-4EBP1; Immunohistochemistry; Prognosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Previous studies have confirmed the role of phosphorylated form of 4E-binding protein 1 (p-4E-BP1) as a good candidate tumor biomarker. The aim of this study was to investigate p-4E-BP1 expression status in hilar cholangiocarcinoma (HCCA) specimens and to clarify its clinical significance. Tissue microarray containing tumor specimens obtained from 61 patients with HCCA were constructed. p-4E-BP1 was investigated by immunohistochemical studies. High/moderate expression p-4E-BP1 was observed in 57.4 % (35/61) primary cancer specimens. Overexpression of p-4E-BP1 protein was associated with poor differentiation and regional lymph node metastasis. Survival analysis and Cox proportional hazards model revealed that p-4E-BP1 overexpression was an independent factor in predicting recurrence-free survival and overall survival for HCCA patients, apart from tumor invasion and complete resection. P-4E-BP1 was highly expressed in HCCA. Overexpressed p-4E-BP1 might be a novel biomarker to predict the clinical outcome of patients with resected HCCA.
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