Senescence comes of age

被引：0
作者：
Masashi Narita
Scott W Lowe
机构：
[1] Cold Spring Harbor Laboratory and Scott W. Lowe is also at the Howard Hughes Medical Institute,
来源：
Nature Medicine | 2005年 / 11卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Normal cells can respond to expression of activated oncogenes by initiating cellular senescence, a permanent state of proliferative arrest. But whether this process reflects a relevant anticancer mechanism has been debated. Several studies now show that oncogene-induced senescence can occur in vivo and provides a bona fide barrier to tumorigenesis.
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页码：920 / 922
页数：2
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