A Study of Potential Pharmacokinetic and Pharmacodynamic Interactions between Dextromethorphan/Quinidine and Memantine in Healthy Volunteers

被引：1
|
作者：
Laura E. Pope
Kerri A. Schoedel
Cynthia Bartlett
Edward M. Sellers
机构：
[1] Avanir Pharmaceuticals,Clinical Research
[2] Inc.,undefined
[3] INC Research — Toronto,undefined
[4] DL Global Partners Inc.,undefined
来源：
Clinical Drug Investigation | 2012年 / 32卷 / 8期
关键词：
Quinidine; Memantine; Dextromethorphan; Beck Anxiety Inventory; Dextrorphan;
D O I：
10.1007/BF03261905
中图分类号：
学科分类号：
摘要：
Background and Objective: Dextromethorphan/quinidine (DMQ) is the first agent indicated for the treatment of pseudobulbar affect. Dextromethorphan, the active ingredient, is a low-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. This study evaluated the potential for a drug-drug interaction (DDI) of DMQ with memantine, which is also an NMDA receptor antagonist.
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页码：e1 / e15
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